STRINGSTRING
ZFAND1 ZFAND1 FKBP6 FKBP6 PPIL4 PPIL4 FMO5 FMO5 CBWD2 CBWD2 C2orf42 C2orf42 LRP12 LRP12 TATDN1 TATDN1 GOLGA6C GOLGA6C DRD5 DRD5 TBL2 TBL2 POMZP3 POMZP3 AKIP1 AKIP1 OR4L1 OR4L1 NPEPPS NPEPPS TRIM50 TRIM50 FAM83F FAM83F RSBN1L RSBN1L DHRS4L2 DHRS4L2 HHIPL2 HHIPL2 ANKRD35 ANKRD35 ANKRD20A4 ANKRD20A4 ZNF98 ZNF98 CBWD3 CBWD3 NOTCH2NLA NOTCH2NLA FAM72A FAM72A GPR89B GPR89B FAM72B FAM72B GPRIN2 GPRIN2 CBWD6 CBWD6 CBWD1 CBWD1 ANKRD20A2 ANKRD20A2 DHRS13 DHRS13 HYDIN HYDIN ANKRD13B ANKRD13B DNAJC30 DNAJC30 FAM72D FAM72D ARHGAP11B ARHGAP11B GTF2IRD1 GTF2IRD1 FRG2B FRG2B GTF2IRD2 GTF2IRD2 TMEM14B TMEM14B NPIPB11 NPIPB11 GLIPR1L2 GLIPR1L2 GTF2I GTF2I ZFP92 ZFP92 NOTCH2NLC NOTCH2NLC FAM72C FAM72C ACP6 ACP6 RNF115 RNF115 NBPF10 NBPF10 NOTCH2NLB NOTCH2NLB NBPF1 NBPF1 LIX1L LIX1L ANKRD34A ANKRD34A NBPF11 NBPF11 ANKRD20A1 ANKRD20A1 SRGAP2C SRGAP2C NBPF19-2 NBPF19-2 SEC14L2 SEC14L2 GTF2IRD2B GTF2IRD2B ARHGAP11B-2 ARHGAP11B-2 ANKRD20A3 ANKRD20A3 OR2T35 OR2T35 SRGAP2B SRGAP2B OR2T10 OR2T10 OR2G6 OR2G6 NBPF19 NBPF19
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFAND1AN1-type zinc finger protein 1; Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during [...] (268 aa)
FKBP6Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be re [...] (327 aa)
PPIL4Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily. (492 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. (533 aa)
CBWD2COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. (395 aa)
C2orf42Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. (574 aa)
LRP12Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family. (859 aa)
TATDN1Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. (297 aa)
GOLGA6CGolgin A6 family member C; Belongs to the GOLGA6 family. (693 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (477 aa)
TBL2Transducin beta like 2. (447 aa)
POMZP3POM121 and ZP3 fusion. (187 aa)
AKIP1A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. (210 aa)
OR4L1Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
NPEPPSPuromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. (919 aa)
TRIM50E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family. (487 aa)
FAM83FProtein FAM83F; Family with sequence similarity 83 member F. (500 aa)
RSBN1LLysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family. (846 aa)
DHRS4L2Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. (232 aa)
HHIPL2HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family. (724 aa)
ANKRD35Ankyrin repeat domain 35. (1001 aa)
ANKRD20A4Ankyrin repeat domain-containing protein 20A4. (823 aa)
ZNF98Zinc finger protein 98; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (572 aa)
CBWD3COBW domain containing 3. (395 aa)
NOTCH2NLANotch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] (236 aa)
FAM72AProtein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Belongs to the FAM72 family. (149 aa)
GPR89BG protein-coupled receptor 89B. (455 aa)
FAM72BProtein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. (149 aa)
GPRIN2G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. (458 aa)
CBWD6COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. (395 aa)
CBWD1COBW domain containing 1. (395 aa)
ANKRD20A2Ankyrin repeat domain-containing protein 20A2. (823 aa)
DHRS13Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. (377 aa)
HYDINHydrocephalus-inducing protein homolog; Required for ciliary motility. (5121 aa)
ANKRD13BAnkyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. (626 aa)
DNAJC30DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). (226 aa)
FAM72DProtein FAM72D; Family with sequence similarity 72 member D. (149 aa)
ARHGAP11BRho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity. (267 aa)
GTF2IRD1General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow- twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). (976 aa)
FRG2BProtein FRG2-like-1; FSHD region gene 2 family member B. (278 aa)
GTF2IRD2General transcription factor II-I repeat domain-containing protein 2A; GTF2I repeat domain containing 2. (949 aa)
TMEM14BTransmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions. (151 aa)
NPIPB11Nuclear pore complex interacting protein family member B11. (1161 aa)
GLIPR1L2GLIPR1-like protein 2; GLIPR1 like 2; Belongs to the CRISP family. (344 aa)
GTF2IGeneral transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] (998 aa)
ZFP92Zinc finger protein 92 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (416 aa)
NOTCH2NLCNotch 2 N-terminal like C. (236 aa)
FAM72CProtein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family. (149 aa)
ACP6Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Belongs to the histidine acid phosphatase family. (428 aa)
RNF115E3 ubiquitin-protein ligase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. (304 aa)
NBPF10Neuroblastoma breakpoint family member 10; NBPF member 10. (3795 aa)
NOTCH2NLBNotch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] (249 aa)
NBPF1Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. (1139 aa)
LIX1LLIX1-like protein; Limb and CNS expressed 1 like; Belongs to the LIX1 family. (337 aa)
ANKRD34AAnkyrin repeat domain 34A. (496 aa)
NBPF11Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family. (865 aa)
ANKRD20A1Ankyrin repeat domain-containing protein 20A1; Ankyrin repeat domain 20 family member A1. (823 aa)
SRGAP2CSLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. (459 aa)
NBPF19-2Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. (3843 aa)
SEC14L2SEC14-like protein 2; Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha- tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. (403 aa)
GTF2IRD2BGeneral transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family. (949 aa)
ARHGAP11B-2Rho GTPase activating protein 11B. (267 aa)
ANKRD20A3Ankyrin repeat domain-containing protein 20A3. (823 aa)
OR2T35Olfactory receptor 2T35; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (323 aa)
SRGAP2BSLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. (459 aa)
OR2T10Olfactory receptor 2T10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
OR2G6Olfactory receptor 2G6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (316 aa)
NBPF19NBPF member 19. (3843 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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