STRINGSTRING
CBWD2 CBWD2 DHRS4L2 DHRS4L2 ANKRD20A4 ANKRD20A4 CBWD3 CBWD3 NOTCH2NLA NOTCH2NLA FAM72A FAM72A FAM72B FAM72B CBWD6 CBWD6 CBWD1 CBWD1 FAM72D FAM72D ARHGAP11B ARHGAP11B TMEM14B TMEM14B FAM72C FAM72C NOTCH2NLB NOTCH2NLB ANKRD20A1 ANKRD20A1 SRGAP2C SRGAP2C ARHGAP11B-2 ARHGAP11B-2 ANKRD20A3 ANKRD20A3 SRGAP2B SRGAP2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBWD2COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. (395 aa)
DHRS4L2Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. (232 aa)
ANKRD20A4Ankyrin repeat domain-containing protein 20A4. (823 aa)
CBWD3COBW domain containing 3. (395 aa)
NOTCH2NLANotch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] (236 aa)
FAM72AProtein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Belongs to the FAM72 family. (149 aa)
FAM72BProtein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. (149 aa)
CBWD6COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. (395 aa)
CBWD1COBW domain containing 1. (395 aa)
FAM72DProtein FAM72D; Family with sequence similarity 72 member D. (149 aa)
ARHGAP11BRho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity. (267 aa)
TMEM14BTransmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions. (151 aa)
FAM72CProtein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family. (149 aa)
NOTCH2NLBNotch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] (249 aa)
ANKRD20A1Ankyrin repeat domain-containing protein 20A1; Ankyrin repeat domain 20 family member A1. (823 aa)
SRGAP2CSLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. (459 aa)
ARHGAP11B-2Rho GTPase activating protein 11B. (267 aa)
ANKRD20A3Ankyrin repeat domain-containing protein 20A3. (823 aa)
SRGAP2BSLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. (459 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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