(5 nodes) Mixed, incl. Essential tremor, and Olduvai domain network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRP12	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family. (859 aa)
	OR4L1	Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	NOTCH2NLC	Notch 2 N-terminal like C. (236 aa)
	NBPF19-2	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family. (3843 aa)
	NBPF19	NBPF member 19. (3843 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LRP12	NBPF19	ENSP00000276654	ENSP00000498781	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	NBPF member 19.	0.546
LRP12	NBPF19-2	ENSP00000276654	ENSP00000478752	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	0.545
LRP12	NOTCH2NLC	ENSP00000276654	ENSP00000462298	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	Notch 2 N-terminal like C.	0.722
NBPF19	LRP12	ENSP00000498781	ENSP00000276654	NBPF member 19.	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	0.546
NBPF19	NOTCH2NLC	ENSP00000498781	ENSP00000462298	NBPF member 19.	Notch 2 N-terminal like C.	0.791
NBPF19	OR4L1	ENSP00000498781	ENSP00000319217	NBPF member 19.	Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.581
NBPF19-2	LRP12	ENSP00000478752	ENSP00000276654	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	0.545
NBPF19-2	NOTCH2NLC	ENSP00000478752	ENSP00000462298	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	Notch 2 N-terminal like C.	0.791
NBPF19-2	OR4L1	ENSP00000478752	ENSP00000319217	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.580
NOTCH2NLC	LRP12	ENSP00000462298	ENSP00000276654	Notch 2 N-terminal like C.	Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family.	0.722
NOTCH2NLC	NBPF19	ENSP00000462298	ENSP00000498781	Notch 2 N-terminal like C.	NBPF member 19.	0.791
NOTCH2NLC	NBPF19-2	ENSP00000462298	ENSP00000478752	Notch 2 N-terminal like C.	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	0.791
OR4L1	NBPF19	ENSP00000319217	ENSP00000498781	Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	NBPF member 19.	0.581
OR4L1	NBPF19-2	ENSP00000319217	ENSP00000478752	Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	0.580