STRINGSTRING
MLF2 MLF2 CNIH1 CNIH1 KCTD9 KCTD9 ABTB1 ABTB1 MIIP MIIP MEGF8 MEGF8 TMCO6 TMCO6 CHI3L1 CHI3L1 ADAMDEC1 ADAMDEC1 ANO3 ANO3 KCTD3 KCTD3 MGRN1 MGRN1 ATRN ATRN CRACD CRACD RNF157 RNF157 PNKD PNKD HIRIP3 HIRIP3 CLDND2 CLDND2 SHKBP1 SHKBP1 C16orf92 C16orf92 TMEM145 TMEM145 OR2K2 OR2K2 SNED1 SNED1 MLC1 MLC1 ASPHD1 ASPHD1 OR4B1 OR4B1 KCTD14 KCTD14 SHISA3 SHISA3 C16orf54 C16orf54 KANK3 KANK3 SLX1B SLX1B SYNDIG1L SYNDIG1L ZNF789 ZNF789 C3orf70 C3orf70 SLX4IP SLX4IP ZNF224 ZNF224 KCTD21 KCTD21 KRCC1 KRCC1 LRRC66 LRRC66 IFITM10 IFITM10 GFI1B GFI1B ATRNL1 ATRNL1 ARHGAP19 ARHGAP19 KCTD18 KCTD18 KCTD8 KCTD8 PCED1A PCED1A ZFP69B ZFP69B ZNF511 ZNF511 GPATCH2 GPATCH2 ZNF511-PRAP1 ZNF511-PRAP1 CYB561D1 CYB561D1 KCTD20 KCTD20 CARD19 CARD19 SUSD3 SUSD3 SYNDIG1 SYNDIG1 KCTD12 KCTD12 SCGN SCGN TLCD3B TLCD3B VWA3A VWA3A TMEM91 TMEM91 STK16 STK16 YPEL3 YPEL3 CEP162 CEP162 ELFN2 ELFN2 RNF24 RNF24 GSG1L GSG1L TMEM233 TMEM233 ZNF230 ZNF230 DEPDC1 DEPDC1 ZNF177 ZNF177 CNIH4 CNIH4 KCTD16 KCTD16 ANKRD46 ANKRD46 BTBD10 BTBD10 CRACR2B CRACR2B CIZ1 CIZ1 PDZD9 PDZD9 PRR19 PRR19 MOSMO MOSMO PRRT2 PRRT2 TMEM219 TMEM219 BOLA2-SMG1P6 BOLA2-SMG1P6 FAM222B FAM222B MISP3 MISP3 GSG1L2 GSG1L2 U3KQ87_HUMAN U3KQ87_HUMAN SEZ6L2 SEZ6L2 ZNF322 ZNF322 DOC2A DOC2A LOC112694756 LOC112694756 PRRT1B PRRT1B
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLF2Myeloid leukemia factor 2. (248 aa)
CNIH1Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family. (144 aa)
KCTD9BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. (389 aa)
ABTB1Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes. (478 aa)
MIIPMigration and invasion-inhibitory protein; Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. (388 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. (2845 aa)
TMCO6Transmembrane and coiled-coil domains 6. (499 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (383 aa)
ADAMDEC1ADAM DEC1; May play an important role in the control of the immune response and during pregnancy. (470 aa)
ANO3Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. (981 aa)
KCTD3BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family. (815 aa)
MGRN1E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). (576 aa)
ATRNAttractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). (1429 aa)
CRACDCapping protein inhibiting regulator of actin dynamics; Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. (1233 aa)
RNF157E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle. (679 aa)
PNKDProbable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (385 aa)
HIRIP3HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. (556 aa)
CLDND2Claudin domain containing 2. (167 aa)
SHKBP1SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. Belongs to the KCTD3 family. (707 aa)
C16orf92Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. (132 aa)
TMEM145Transmembrane protein 145. (493 aa)
OR2K2Olfactory receptor 2K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (316 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1413 aa)
MLC1Membrane protein MLC1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. (377 aa)
ASPHD1Aspartate beta-hydroxylase domain containing 1. (390 aa)
OR4B1Olfactory receptor 4B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa)
KCTD14BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. (255 aa)
SHISA3Protein shisa-3 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. (238 aa)
C16orf54Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. (224 aa)
KANK3KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. (821 aa)
SLX1BSLX1 homolog B, structure-specific endonuclease subunit. (275 aa)
SYNDIG1LSynapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. (238 aa)
ZNF789Zinc finger protein 789; May be involved in transcriptional regulation. (425 aa)
C3orf70UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development. (250 aa)
SLX4IPSLX4 interacting protein. (408 aa)
ZNF224Zinc finger protein 224; May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Belongs to the krueppel C2H2-type zinc-finger protein family. (707 aa)
KCTD21BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). (260 aa)
KRCC1Lysine rich coiled-coil 1. (259 aa)
LRRC66Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66. (880 aa)
IFITM10Interferon induced transmembrane protein 10. (228 aa)
GFI1BZinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] (330 aa)
ATRNL1Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis. (1379 aa)
ARHGAP19Rho GTPase-activating protein 19; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (494 aa)
KCTD18BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. (426 aa)
KCTD8BTB/POZ domain-containing protein KCTD8; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). (473 aa)
PCED1APC-esterase domain containing 1A; Belongs to the PC-esterase family. (454 aa)
ZFP69BZinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. (534 aa)
ZNF511Zinc finger protein 511; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (252 aa)
GPATCH2G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro. (528 aa)
ZNF511-PRAP1ZNF511-PRAP1 readthrough. (318 aa)
CYB561D1Cytochrome b561 family member D1. (251 aa)
KCTD20BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. (419 aa)
CARD19Caspase recruitment domain-containing protein 19; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. (183 aa)
SUSD3Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration. (255 aa)
SYNDIG1Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin family. (258 aa)
KCTD12BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). (325 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
TLCD3BCeramide synthase; Involved in ceramide synthesis. (274 aa)
VWA3AVon Willebrand factor A domain containing 3A. (1184 aa)
TMEM91Transmembrane protein 91; Belongs to the CD225/Dispanin family. (172 aa)
STK16Serine/threonine-protein kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. (305 aa)
YPEL3Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. (157 aa)
CEP162Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. Belongs to the CEP162 family. (1403 aa)
ELFN2Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. (820 aa)
RNF24RING finger protein 24; May play a role in TRPCs intracellular trafficking. (169 aa)
GSG1LGerm cell-specific gene 1-like protein; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating. (331 aa)
TMEM233Transmembrane protein 233. (109 aa)
ZNF230Zinc finger protein 230; May be involved in transcriptional regulation. (474 aa)
DEPDC1DEP domain-containing protein 1A; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. (811 aa)
ZNF177Zinc finger protein 177; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (481 aa)
CNIH4Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Belongs to the cornichon family. (139 aa)
KCTD16BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). (428 aa)
ANKRD46Ankyrin repeat domain 46. (232 aa)
BTBD10BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. (483 aa)
CRACR2BEF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE). (399 aa)
CIZ1Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. (954 aa)
PDZD9PDZ domain containing 9. (204 aa)
PRR19Proline-rich protein 19; Proline rich 19. (356 aa)
MOSMOModulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. (167 aa)
PRRT2Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. (394 aa)
TMEM219Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. (240 aa)
BOLA2-SMG1P6BOLA2-SMG1P6 readthrough. (249 aa)
FAM222BProtein FAM222B; Family with sequence similarity 222 member B; Belongs to the FAM222 family. (562 aa)
MISP3Uncharacterized protein MISP3; MISP family member 3; Belongs to the MISP family. (219 aa)
GSG1L2Germ cell-specific gene 1-like protein 2; GSG1 like 2. (293 aa)
U3KQ87_HUMANUncharacterized protein. (197 aa)
SEZ6L2Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. (923 aa)
ZNF322Zinc finger protein 322; Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. (402 aa)
DOC2ADouble C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. (400 aa)
LOC112694756Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (368 aa)
PRRT1BProline rich transmembrane protein 1B. (263 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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