STRINGSTRING
MLF2 MLF2 CHI3L1 CHI3L1 ANO3 ANO3 PNKD PNKD HIRIP3 HIRIP3 C16orf92 C16orf92 ASPHD1 ASPHD1 OR4B1 OR4B1 C16orf54 C16orf54 SLX1B SLX1B SCGN SCGN TLCD3B TLCD3B YPEL3 YPEL3 CIZ1 CIZ1 PRRT2 PRRT2 TMEM219 TMEM219 BOLA2-SMG1P6 BOLA2-SMG1P6 SEZ6L2 SEZ6L2 DOC2A DOC2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLF2Myeloid leukemia factor 2. (248 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (383 aa)
ANO3Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. (981 aa)
PNKDProbable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (385 aa)
HIRIP3HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. (556 aa)
C16orf92Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. (132 aa)
ASPHD1Aspartate beta-hydroxylase domain containing 1. (390 aa)
OR4B1Olfactory receptor 4B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa)
C16orf54Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. (224 aa)
SLX1BSLX1 homolog B, structure-specific endonuclease subunit. (275 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
TLCD3BCeramide synthase; Involved in ceramide synthesis. (274 aa)
YPEL3Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. (157 aa)
CIZ1Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. (954 aa)
PRRT2Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. (394 aa)
TMEM219Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. (240 aa)
BOLA2-SMG1P6BOLA2-SMG1P6 readthrough. (249 aa)
SEZ6L2Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. (923 aa)
DOC2ADouble C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. (400 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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