(12 nodes) 16p11.2 proximal deletion syndrome, and Myeloid leukemia factor network (Homo sapiens)

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Your Input:
	MLF2	Myeloid leukemia factor 2. (248 aa)
	CHI3L1	Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (383 aa)
	HIRIP3	HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. (556 aa)
	C16orf92	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. (132 aa)
	ASPHD1	Aspartate beta-hydroxylase domain containing 1. (390 aa)
	C16orf54	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. (224 aa)
	SCGN	Secretagogin, EF-hand calcium binding protein. (276 aa)
	TLCD3B	Ceramide synthase; Involved in ceramide synthesis. (274 aa)
	YPEL3	Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. (157 aa)
	TMEM219	Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. (240 aa)
	SEZ6L2	Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. (923 aa)
	DOC2A	Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. (400 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPHD1	C16orf54	ENSP00000311447	ENSP00000327506	Aspartate beta-hydroxylase domain containing 1.	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	0.803
ASPHD1	C16orf92	ENSP00000311447	ENSP00000300575	Aspartate beta-hydroxylase domain containing 1.	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	0.679
ASPHD1	DOC2A	ENSP00000311447	ENSP00000482870	Aspartate beta-hydroxylase domain containing 1.	Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.	0.684
ASPHD1	HIRIP3	ENSP00000311447	ENSP00000279392	Aspartate beta-hydroxylase domain containing 1.	HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.	0.693
ASPHD1	SEZ6L2	ENSP00000311447	ENSP00000481917	Aspartate beta-hydroxylase domain containing 1.	Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family.	0.869
ASPHD1	TLCD3B	ENSP00000311447	ENSP00000369863	Aspartate beta-hydroxylase domain containing 1.	Ceramide synthase; Involved in ceramide synthesis.	0.612
ASPHD1	TMEM219	ENSP00000311447	ENSP00000457492	Aspartate beta-hydroxylase domain containing 1.	Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding.	0.632
ASPHD1	YPEL3	ENSP00000311447	ENSP00000381821	Aspartate beta-hydroxylase domain containing 1.	Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells.	0.687
C16orf54	ASPHD1	ENSP00000327506	ENSP00000311447	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Aspartate beta-hydroxylase domain containing 1.	0.803
C16orf54	C16orf92	ENSP00000327506	ENSP00000300575	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	0.692
C16orf54	DOC2A	ENSP00000327506	ENSP00000482870	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.	0.600
C16orf54	HIRIP3	ENSP00000327506	ENSP00000279392	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.	0.664
C16orf54	SEZ6L2	ENSP00000327506	ENSP00000481917	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family.	0.609
C16orf54	TLCD3B	ENSP00000327506	ENSP00000369863	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Ceramide synthase; Involved in ceramide synthesis.	0.545
C16orf54	TMEM219	ENSP00000327506	ENSP00000457492	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding.	0.661
C16orf54	YPEL3	ENSP00000327506	ENSP00000381821	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells.	0.600
C16orf92	ASPHD1	ENSP00000300575	ENSP00000311447	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Aspartate beta-hydroxylase domain containing 1.	0.679
C16orf92	C16orf54	ENSP00000300575	ENSP00000327506	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.	0.692
C16orf92	DOC2A	ENSP00000300575	ENSP00000482870	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.	0.626
C16orf92	HIRIP3	ENSP00000300575	ENSP00000279392	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.	0.602