| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANO3 | CIZ1 | ENSP00000256737 | ENSP00000439244 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | 0.787 |
| ANO3 | OR4B1 | ENSP00000256737 | ENSP00000311605 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | Olfactory receptor 4B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.447 |
| ANO3 | PNKD | ENSP00000256737 | ENSP00000273077 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.475 |
| ANO3 | PRRT2 | ENSP00000256737 | ENSP00000456226 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.571 |
| CIZ1 | ANO3 | ENSP00000439244 | ENSP00000256737 | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.787 |
| CIZ1 | PNKD | ENSP00000439244 | ENSP00000273077 | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.481 |
| CIZ1 | PRRT2 | ENSP00000439244 | ENSP00000456226 | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.643 |
| OR4B1 | ANO3 | ENSP00000311605 | ENSP00000256737 | Olfactory receptor 4B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.447 |
| PNKD | ANO3 | ENSP00000273077 | ENSP00000256737 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.475 |
| PNKD | CIZ1 | ENSP00000273077 | ENSP00000439244 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | 0.481 |
| PNKD | PRRT2 | ENSP00000273077 | ENSP00000456226 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.963 |
| PRRT2 | ANO3 | ENSP00000456226 | ENSP00000256737 | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.571 |
| PRRT2 | CIZ1 | ENSP00000456226 | ENSP00000439244 | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1. | 0.643 |
| PRRT2 | PNKD | ENSP00000456226 | ENSP00000273077 | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.963 |