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WDR70 WDR70 RNF165 RNF165 SFXN5 SFXN5 LMBRD2 LMBRD2 HDHD2 HDHD2 SRARP SRARP TMEM181 TMEM181 CACUL1 CACUL1 CPLANE1 CPLANE1 BARGIN BARGIN TMEM267 TMEM267 KBTBD4 KBTBD4 FAM214A FAM214A TMEM200C TMEM200C ELOA3B ELOA3B C18orf25 C18orf25 SPTY2D1OS SPTY2D1OS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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WDR70WD repeat domain 70; Belongs to the WD repeat GAD-1 family. (654 aa)
RNF165E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Belongs to the Arkadia family. (346 aa)
SFXN5Sideroflexin-5; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Transports citrate (By similarity). (340 aa)
LMBRD2G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. (695 aa)
HDHD2Haloacid dehalogenase like hydrolase domain containing 2. (259 aa)
SRARPSteroid receptor-associated and regulated protein; May regulate the transcriptional function of androgen and estrogen receptors. (169 aa)
TMEM181Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. (612 aa)
CACUL1CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. (369 aa)
CPLANE1Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT- A proteins to basal bodies (By similarity). (3197 aa)
BARGINBargin; GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. (605 aa)
TMEM267Transmembrane protein 267. (215 aa)
KBTBD4Kelch repeat and BTB domain containing 4. (543 aa)
FAM214AProtein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. (1083 aa)
TMEM200CTransmembrane protein 200C. (621 aa)
ELOA3BElongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). (546 aa)
C18orf25Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. (404 aa)
SPTY2D1OSPutative transmembrane protein SPTY2D1OS; SPTY2D1 opposite strand. (59 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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