| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BARGIN | HDHD2 | ENSP00000401076 | ENSP00000300605 | Bargin; GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. | Haloacid dehalogenase like hydrolase domain containing 2. | 0.406 |
| C18orf25 | ELOA3B | ENSP00000481626 | ENSP00000479069 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | Elongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | 0.416 |
| C18orf25 | RNF165 | ENSP00000481626 | ENSP00000269439 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Belongs to the Arkadia family. | 0.645 |
| C18orf25 | TMEM200C | ENSP00000481626 | ENSP00000463375 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | Transmembrane protein 200C. | 0.479 |
| CACUL1 | KBTBD4 | ENSP00000358147 | ENSP00000436713 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. | Kelch repeat and BTB domain containing 4. | 0.616 |
| CPLANE1 | WDR70 | ENSP00000389014 | ENSP00000265107 | Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT- A proteins to basal bodies (By similarity). | WD repeat domain 70; Belongs to the WD repeat GAD-1 family. | 0.935 |
| ELOA3B | C18orf25 | ENSP00000479069 | ENSP00000481626 | Elongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25. | 0.416 |
| ELOA3B | HDHD2 | ENSP00000479069 | ENSP00000300605 | Elongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | Haloacid dehalogenase like hydrolase domain containing 2. | 0.418 |
| FAM214A | KBTBD4 | ENSP00000443598 | ENSP00000436713 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. | Kelch repeat and BTB domain containing 4. | 0.416 |
| FAM214A | LMBRD2 | ENSP00000443598 | ENSP00000296603 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. | G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. | 0.573 |
| HDHD2 | BARGIN | ENSP00000300605 | ENSP00000401076 | Haloacid dehalogenase like hydrolase domain containing 2. | Bargin; GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. | 0.406 |
| HDHD2 | ELOA3B | ENSP00000300605 | ENSP00000479069 | Haloacid dehalogenase like hydrolase domain containing 2. | Elongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | 0.418 |
| HDHD2 | LMBRD2 | ENSP00000300605 | ENSP00000296603 | Haloacid dehalogenase like hydrolase domain containing 2. | G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. | 0.432 |
| HDHD2 | TMEM267 | ENSP00000300605 | ENSP00000426067 | Haloacid dehalogenase like hydrolase domain containing 2. | Transmembrane protein 267. | 0.474 |
| HDHD2 | WDR70 | ENSP00000300605 | ENSP00000265107 | Haloacid dehalogenase like hydrolase domain containing 2. | WD repeat domain 70; Belongs to the WD repeat GAD-1 family. | 0.475 |
| KBTBD4 | CACUL1 | ENSP00000436713 | ENSP00000358147 | Kelch repeat and BTB domain containing 4. | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. | 0.616 |
| KBTBD4 | FAM214A | ENSP00000436713 | ENSP00000443598 | Kelch repeat and BTB domain containing 4. | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. | 0.416 |
| LMBRD2 | FAM214A | ENSP00000296603 | ENSP00000443598 | G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. | 0.573 |
| LMBRD2 | HDHD2 | ENSP00000296603 | ENSP00000300605 | G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. | Haloacid dehalogenase like hydrolase domain containing 2. | 0.432 |
| LMBRD2 | TMEM267 | ENSP00000296603 | ENSP00000426067 | G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. | Transmembrane protein 267. | 0.485 |