(7 nodes) Mixed, incl. Joubert syndrome 17, and Atos-like, C-terminal network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WDR70	WD repeat domain 70; Belongs to the WD repeat GAD-1 family. (654 aa)
	LMBRD2	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family. (695 aa)
	HDHD2	Haloacid dehalogenase like hydrolase domain containing 2. (259 aa)
	SRARP	Steroid receptor-associated and regulated protein; May regulate the transcriptional function of androgen and estrogen receptors. (169 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT- A proteins to basal bodies (By similarity). (3197 aa)
	TMEM267	Transmembrane protein 267. (215 aa)
	FAM214A	Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family. (1083 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPLANE1	WDR70	ENSP00000389014	ENSP00000265107	Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT- A proteins to basal bodies (By similarity).	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.935
FAM214A	LMBRD2	ENSP00000443598	ENSP00000296603	Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family.	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	0.573
HDHD2	LMBRD2	ENSP00000300605	ENSP00000296603	Haloacid dehalogenase like hydrolase domain containing 2.	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	0.432
HDHD2	TMEM267	ENSP00000300605	ENSP00000426067	Haloacid dehalogenase like hydrolase domain containing 2.	Transmembrane protein 267.	0.474
HDHD2	WDR70	ENSP00000300605	ENSP00000265107	Haloacid dehalogenase like hydrolase domain containing 2.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.475
LMBRD2	FAM214A	ENSP00000296603	ENSP00000443598	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family.	0.573
LMBRD2	HDHD2	ENSP00000296603	ENSP00000300605	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	Haloacid dehalogenase like hydrolase domain containing 2.	0.432
LMBRD2	TMEM267	ENSP00000296603	ENSP00000426067	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	Transmembrane protein 267.	0.485
LMBRD2	WDR70	ENSP00000296603	ENSP00000265107	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.443
TMEM267	HDHD2	ENSP00000426067	ENSP00000300605	Transmembrane protein 267.	Haloacid dehalogenase like hydrolase domain containing 2.	0.474
TMEM267	LMBRD2	ENSP00000426067	ENSP00000296603	Transmembrane protein 267.	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	0.485
TMEM267	WDR70	ENSP00000426067	ENSP00000265107	Transmembrane protein 267.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.580
WDR70	CPLANE1	ENSP00000265107	ENSP00000389014	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT- A proteins to basal bodies (By similarity).	0.935
WDR70	HDHD2	ENSP00000265107	ENSP00000300605	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	Haloacid dehalogenase like hydrolase domain containing 2.	0.475
WDR70	LMBRD2	ENSP00000265107	ENSP00000296603	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	0.443
WDR70	TMEM267	ENSP00000265107	ENSP00000426067	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	Transmembrane protein 267.	0.580