(6 nodes) Mixed, incl. RNA-binding protein Nova-1/2, type I K Homology domain 3, and Protein of unknown function (DUF1151) network (Homo sapiens)

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Your Input:
	FAM107B	Protein FAM107B; Family with sequence similarity 107 member B. (306 aa)
	GLRA2	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol. (452 aa)
	NOVA2	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA. (492 aa)
	SRRM4	Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to pr [...] (611 aa)
	PTBP2	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. (537 aa)
	NOVA1	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons. (507 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM107B	GLRA2	ENSP00000181796	ENSP00000218075	Protein FAM107B; Family with sequence similarity 107 member B.	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	0.557
FAM107B	NOVA1	ENSP00000181796	ENSP00000438875	Protein FAM107B; Family with sequence similarity 107 member B.	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	0.847
FAM107B	NOVA2	ENSP00000181796	ENSP00000263257	Protein FAM107B; Family with sequence similarity 107 member B.	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	0.853
FAM107B	PTBP2	ENSP00000181796	ENSP00000359216	Protein FAM107B; Family with sequence similarity 107 member B.	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	0.432
GLRA2	FAM107B	ENSP00000218075	ENSP00000181796	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	Protein FAM107B; Family with sequence similarity 107 member B.	0.557
GLRA2	NOVA1	ENSP00000218075	ENSP00000438875	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	0.850
GLRA2	NOVA2	ENSP00000218075	ENSP00000263257	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	0.610
NOVA1	FAM107B	ENSP00000438875	ENSP00000181796	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	Protein FAM107B; Family with sequence similarity 107 member B.	0.847
NOVA1	GLRA2	ENSP00000438875	ENSP00000218075	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	0.850
NOVA1	NOVA2	ENSP00000438875	ENSP00000263257	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	0.770
NOVA1	PTBP2	ENSP00000438875	ENSP00000359216	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	0.870
NOVA1	SRRM4	ENSP00000438875	ENSP00000267260	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to pr [...]	0.673
NOVA2	FAM107B	ENSP00000263257	ENSP00000181796	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	Protein FAM107B; Family with sequence similarity 107 member B.	0.853
NOVA2	GLRA2	ENSP00000263257	ENSP00000218075	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.	0.610
NOVA2	NOVA1	ENSP00000263257	ENSP00000438875	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	0.770
NOVA2	PTBP2	ENSP00000263257	ENSP00000359216	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	0.893
NOVA2	SRRM4	ENSP00000263257	ENSP00000267260	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to pr [...]	0.662
PTBP2	FAM107B	ENSP00000359216	ENSP00000181796	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	Protein FAM107B; Family with sequence similarity 107 member B.	0.432
PTBP2	NOVA1	ENSP00000359216	ENSP00000438875	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.	0.870
PTBP2	NOVA2	ENSP00000359216	ENSP00000263257	Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.	RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	0.893