16 items (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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gene neighborhood

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Your Input:
	C1orf35	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35. (263 aa)
	LRRC14	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. (493 aa)
	PPP1R16A	Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. (528 aa)
	ADCK5	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). (580 aa)
	GRINA	Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. (371 aa)
	FBXL6	F-box/LRR-repeat protein 6; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (539 aa)
	GLI4	GLI family zinc finger 4. (376 aa)
	STK19	Serine/threonine-protein kinase 19; Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors. Belongs to the STK19 family. (368 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1114 aa)
	CNKSR2	Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways. (1034 aa)
	TMBIM6	Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). (295 aa)
	TNXB	Tenascin-X; Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. (673 aa)
	CYHR1	Cysteine and histidine rich 1; Belongs to the CYHR1 family. (404 aa)
	LRRC24	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24. (513 aa)
	MROH1	Maestro heat like repeat family member 1. (1641 aa)
	SLC52A2	Solute carrier family 52, riboflavin transporter, member 2; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4- hydroxybutyrate (Probable). (445 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCK5	CYHR1	ENSP00000310547	ENSP00000433769	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Cysteine and histidine rich 1; Belongs to the CYHR1 family.	0.546
ADCK5	FBXL6	ENSP00000310547	ENSP00000330098	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	F-box/LRR-repeat protein 6; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	0.693
ADCK5	GRINA	ENSP00000310547	ENSP00000314380	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily.	0.434
ADCK5	LRRC14	ENSP00000310547	ENSP00000292524	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily.	0.580
ADCK5	LRRC24	ENSP00000310547	ENSP00000434849	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24.	0.488
ADCK5	MROH1	ENSP00000310547	ENSP00000435565	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Maestro heat like repeat family member 1.	0.614
ADCK5	PPP1R16A	ENSP00000310547	ENSP00000292539	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.	0.552
ADCK5	SLC52A2	ENSP00000310547	ENSP00000496184	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	Solute carrier family 52, riboflavin transporter, member 2; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4- hydroxybutyrate (Probable).	0.587
ARHGAP39	CNKSR2	ENSP00000366522	ENSP00000368824	Rho GTPase activating protein 39.	Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways.	0.716
ARHGAP39	CYHR1	ENSP00000366522	ENSP00000433769	Rho GTPase activating protein 39.	Cysteine and histidine rich 1; Belongs to the CYHR1 family.	0.704
ARHGAP39	GRINA	ENSP00000366522	ENSP00000314380	Rho GTPase activating protein 39.	Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily.	0.475
ARHGAP39	LRRC14	ENSP00000366522	ENSP00000292524	Rho GTPase activating protein 39.	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily.	0.497
ARHGAP39	LRRC24	ENSP00000366522	ENSP00000434849	Rho GTPase activating protein 39.	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24.	0.415
ARHGAP39	MROH1	ENSP00000366522	ENSP00000435565	Rho GTPase activating protein 39.	Maestro heat like repeat family member 1.	0.724
ARHGAP39	PPP1R16A	ENSP00000366522	ENSP00000292539	Rho GTPase activating protein 39.	Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.	0.591
C1orf35	GLI4	ENSP00000272139	ENSP00000345024	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35.	GLI family zinc finger 4.	0.430
C1orf35	LRRC14	ENSP00000272139	ENSP00000292524	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35.	Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily.	0.466
C1orf35	LRRC24	ENSP00000272139	ENSP00000434849	Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35.	Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24.	0.446
CNKSR2	ARHGAP39	ENSP00000368824	ENSP00000366522	Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways.	Rho GTPase activating protein 39.	0.716
CYHR1	ADCK5	ENSP00000433769	ENSP00000310547	Cysteine and histidine rich 1; Belongs to the CYHR1 family.	Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	0.546