STRINGSTRING
ABCC6 ABCC6 EFS EFS MGP MGP GGCX GGCX PRRG2 PRRG2 TMEM60 TMEM60 TMEM63B TMEM63B ADAM18 ADAM18 RCN3 RCN3 C11orf52 C11orf52 TMEM86A TMEM86A ANKH ANKH HEPACAM HEPACAM TMEM63C TMEM63C PIEZO1 PIEZO1 NEUROD2 NEUROD2 LRRC69 LRRC69 SUSD4 SUSD4 SLC37A1 SLC37A1 FHAD1 FHAD1 TMEM63A TMEM63A PRRG3 PRRG3 C1orf87 C1orf87 ANGPTL2 ANGPTL2 TMEM51 TMEM51 CASZ1 CASZ1 ZNF157 ZNF157 UCMA UCMA ATAD3C ATAD3C LHFPL2 LHFPL2 TMEM87A TMEM87A TMEM203 TMEM203 TMEM121 TMEM121 VKORC1 VKORC1 SEL1L3 SEL1L3 VKORC1L1 VKORC1L1 TMEM120B TMEM120B TMEM150C TMEM150C PRRG1 PRRG1 GDPGP1 GDPGP1 ZFP1 ZFP1 TMEM120A TMEM120A ENSP00000497169 ENSP00000497169
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCC6Multidrug resistance-associated protein 6; [Isoform 1]: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (1503 aa)
EFSEmbryonal Fyn-associated substrate; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). (561 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (128 aa)
GGCXVitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. (758 aa)
PRRG2Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain 2. (202 aa)
TMEM60Transmembrane protein 60. (133 aa)
TMEM63BCSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). (832 aa)
ADAM18Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). (739 aa)
RCN3Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant- associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively r [...] (328 aa)
C11orf52Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52. (123 aa)
TMEM86ALysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A. (240 aa)
ANKHProgressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family. (492 aa)
HEPACAMHepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. (416 aa)
TMEM63CCalcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family. (806 aa)
PIEZO1Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R- Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor t [...] (2521 aa)
NEUROD2Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] (382 aa)
LRRC69Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69. (191 aa)
SUSD4Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. (490 aa)
SLC37A1Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. (533 aa)
FHAD1Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1. (1412 aa)
TMEM63ACSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. (807 aa)
PRRG3Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain 3. (231 aa)
C1orf87Uncharacterized protein C1orf87; Chromosome 1 open reading frame 87. (546 aa)
ANGPTL2Angiopoietin-related protein 2; Induces sprouting in endothelial cells through an autocrine and paracrine action. (493 aa)
TMEM51Transmembrane protein 51. (253 aa)
CASZ1Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. (1759 aa)
ZNF157Zinc finger protein 157; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (506 aa)
UCMAUnique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. (138 aa)
ATAD3CATPase family AAA domain containing 3C; Belongs to the AAA ATPase family. (411 aa)
LHFPL2LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. (228 aa)
TMEM87ATransmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). (555 aa)
TMEM203Transmembrane protein 203; Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis. (136 aa)
TMEM121Transmembrane protein 121; May play a role in MAPK signaling. Belongs to the TMEM121 family. (319 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. (163 aa)
SEL1L3Protein sel-1 homolog 3; SEL1L family member 3. (1132 aa)
VKORC1L1Vitamin K epoxide reductase complex subunit 1-like protein 1; Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. (177 aa)
TMEM120BTransmembrane protein 120B; Necessary for efficient adipogenesis. Belongs to the TMEM120 family. (339 aa)
TMEM150CTransmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs to the DRAM/TMEM150 family. (249 aa)
PRRG1Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. (218 aa)
GDPGP1GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. (385 aa)
ZFP1Zinc finger protein 1 homolog; May be involved in transcriptional regulation. (407 aa)
TMEM120ATransmembrane protein 120A; Necessary for efficient adipogenesis. Belongs to the TMEM120 family. (369 aa)
ENSP00000497169Novel protein. (113 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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