STRINGSTRING
PKP2 PKP2 KRT1 KRT1 DSG3 DSG3 DSG1 DSG1 DSC1 DSC1 DSG2 DSG2 BLMH BLMH PKP1 PKP1 KRT10 KRT10 DSC2 DSC2 PGLYRP3 PGLYRP3 TMEM43 TMEM43 SPRR1B SPRR1B KRT2 KRT2 LCE1D LCE1D RPTN RPTN SPRR3 SPRR3 PKP3 PKP3 SPRR4 SPRR4 LCE5A LCE5A LCE1F LCE1F LCE3C LCE3C LCE1A LCE1A LCE3A LCE3A LCE3B LCE3B PPL PPL KRT77 KRT77 PGLYRP4 PGLYRP4 LCE1B LCE1B DSC3 DSC3 LOR LOR LELP1 LELP1 SPRR2G SPRR2G SPRR2E SPRR2E SPRR2B SPRR2B SPRR2D SPRR2D SPRR1A SPRR1A IVL IVL LCE1E LCE1E C1orf68 C1orf68 LCE4A LCE4A LCE2A LCE2A LCE2B LCE2B LCE2C LCE2C LCE2D LCE2D LCE3D LCE3D LCE3E LCE3E FLG FLG TCHHL1 TCHHL1 CDSN CDSN DSP DSP SERPINB12 SERPINB12 FLG2 FLG2 SPRR2A SPRR2A JUP JUP CASP14 CASP14 PERP PERP LCE6A LCE6A SPRR2F SPRR2F EVPL EVPL LCE1C LCE1C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKP2Plakophilin-2; May play a role in junctional plaques. (881 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. (644 aa)
DSG3Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (999 aa)
DSG1Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1049 aa)
DSC1Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. (894 aa)
DSG2Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1118 aa)
BLMHBleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. (455 aa)
PKP1Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. (747 aa)
KRT10Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. (584 aa)
DSC2Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (901 aa)
PGLYRP3Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (341 aa)
TMEM43Transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). (400 aa)
SPRR1BCornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage; Belongs to the cornifin (SPRR) family. (89 aa)
KRT2Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). (639 aa)
LCE1DLate cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum. (114 aa)
RPTNRepetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. (784 aa)
SPRR3Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. (169 aa)
PKP3Plakophilin-3; May play a role in junctional plaques; Belongs to the beta-catenin family. (797 aa)
SPRR4Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family. (79 aa)
LCE5ALate cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (118 aa)
LCE1FLate cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum. (118 aa)
LCE3CLate cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. (94 aa)
LCE1ALate cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. (110 aa)
LCE3ALate cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family. (89 aa)
LCE3BLate cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. (95 aa)
PPLPeriplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Belongs to the plakin or cytolinker family. (1756 aa)
KRT77Keratin, type II cytoskeletal 1b; Keratin 77. (578 aa)
PGLYRP4Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. (373 aa)
LCE1BLate cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum. (118 aa)
DSC3Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. (896 aa)
LORLoricrin; Major keratinocyte cell envelope protein. (312 aa)
LELP1Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. (98 aa)
SPRR2GSmall proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (73 aa)
SPRR2ESmall proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. (72 aa)
SPRR2BSmall proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. (72 aa)
SPRR2DSmall proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. (72 aa)
SPRR1ACornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. (89 aa)
IVLInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. (585 aa)
LCE1ELate cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum. (118 aa)
C1orf68Skin-specific protein 32; Chromosome 1 open reading frame 68. (250 aa)
LCE4ALate cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (99 aa)
LCE2ALate cornified envelope protein 2A; Precursors of the cornified envelope of the stratum corneum. (106 aa)
LCE2BLate cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum. (110 aa)
LCE2CLate cornified envelope protein 2C; Precursors of the cornified envelope of the stratum. (110 aa)
LCE2DLate cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum. (110 aa)
LCE3DLate cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (92 aa)
LCE3ELate cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum. (92 aa)
FLGFilaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. (4061 aa)
TCHHL1Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. (904 aa)
CDSNCorneodesmosin; Important for the epidermal barrier integrity. (529 aa)
DSPDesmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. (2871 aa)
SERPINB12Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. (425 aa)
FLG2Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. (2391 aa)
SPRR2ASmall proline rich protein 2A. (72 aa)
JUPJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (745 aa)
CASP14Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrie [...] (242 aa)
PERPP53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). (193 aa)
LCE6ALate cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family. (80 aa)
SPRR2FSmall proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). (72 aa)
EVPLEnvoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. (2055 aa)
LCE1CLate cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (118 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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