STRINGSTRING
CNFN CNFN CRNN CRNN SPINK7 SPINK7 DEPP1 DEPP1 KRT78 KRT78 TMPRSS11B TMPRSS11B KRTDAP KRTDAP DMKN DMKN C1orf43 C1orf43 CRCT1 CRCT1 CAPN14 CAPN14 CYSRT1 CYSRT1 SBSN SBSN KPRP KPRP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNFNCornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. (112 aa)
CRNNCornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. (495 aa)
SPINK7Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. (85 aa)
DEPP1Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. (212 aa)
KRT78Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. (520 aa)
TMPRSS11BTransmembrane protease serine 11B; Serine protease. (416 aa)
KRTDAPKeratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. (99 aa)
DMKNDermokine; May act as a soluble regulator of keratinocyte differentiation. (476 aa)
C1orf43Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. (253 aa)
CRCT1Cysteine rich C-terminal 1. (99 aa)
CAPN14Calpain-14; Calcium-regulated non-lysosomal thiol-protease. (684 aa)
CYSRT1Cysteine rich tail 1. (184 aa)
SBSNSuprabasin. (590 aa)
KPRPKeratinocyte proline rich protein. (579 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (12%) [HD]