STRINGSTRING
DMRTC2 DMRTC2 LY6K LY6K PSCA PSCA PATE1 PATE1 LYPD6 LYPD6 ZPBP2 ZPBP2 PATE2 PATE2 LYPD2 LYPD2 LY6G6C LY6G6C LY6G6D LY6G6D LY6G6F LY6G6F LY6G5B LY6G5B LRRC3C LRRC3C LYPD5 LYPD5 LY6G5C LY6G5C LY6G6E LY6G6E PATE3 PATE3 LY6H LY6H GRB7 GRB7 LAX1 LAX1 PATE4 PATE4 LY6E LY6E LY6L LY6L MIEN1 MIEN1 LYPD4 LYPD4 LYNX1 LYNX1 PINLYP PINLYP ANKRD40CL ANKRD40CL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMRTC2Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development. (367 aa)
LY6KLymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. (165 aa)
PSCAProstate stem cell antigen; May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. (114 aa)
PATE1Prostate and testis expressed 1; Belongs to the PATE family. (126 aa)
LYPD6Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). (171 aa)
ZPBP2Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization. (338 aa)
PATE2Prostate and testis expressed 2. (113 aa)
LYPD2LY6/PLAUR domain containing 2. (125 aa)
LY6G6CLymphocyte antigen 6 family member G6C. (125 aa)
LY6G6DLymphocyte antigen 6 family member G6D. (133 aa)
LY6G6FLymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. (297 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (201 aa)
LRRC3CLeucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C. (275 aa)
LYPD5LY6/PLAUR domain containing 5. (251 aa)
LY6G5CLymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation. (150 aa)
LY6G6ELymphocyte antigen 6 family member G6E. (125 aa)
PATE3Prostate and testis expressed 3; Belongs to the PATE family. (98 aa)
LY6HLymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. (161 aa)
GRB7Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...] (555 aa)
LAX1Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. (398 aa)
PATE4Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. (98 aa)
LY6ELymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. (131 aa)
LY6LLymphocyte antigen 6 family member L. (138 aa)
MIEN1Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process; Belongs to the SelWTH family. (116 aa)
LYPD4LY6/PLAUR domain containing 4. (246 aa)
LYNX1Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and e [...] (116 aa)
PINLYPPhospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family. (228 aa)
ANKRD40CLPutative ANKRD40 C-terminal-like protein; ANKRD40 C-terminal like. (114 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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