(27 nodes) Mostly uncharacterized, incl. PHARC syndrome, and Ras GTPase GNL1-like network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNF39	RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance. (420 aa)
	PSORS1C2	Psoriasis susceptibility 1 candidate 2. (136 aa)
	PSORS1C1	Psoriasis susceptibility 1 candidate 1. (152 aa)
	NRM	Nurim. (262 aa)
	CCDC116	Coiled-coil domain containing 116. (613 aa)
	C6orf136	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136. (496 aa)
	TTC32	Tetratricopeptide repeat domain 32. (151 aa)
	ZBTB12	Zinc finger and BTB domain-containing protein 12; May be involved in transcriptional regulation. (459 aa)
	GPANK1	G-patch domain and ankyrin repeats 1. (356 aa)
	C6orf47	Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47. (294 aa)
	PRRC2A	Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. (2157 aa)
	LST1	Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. (104 aa)
	NFKBIL1	NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. (381 aa)
	MCCD1	Mitochondrial coiled-coil domain 1. (119 aa)
	TCF19	Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. (345 aa)
	GNL1	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster. (607 aa)
	ZNF311	Zinc finger protein 311; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (666 aa)
	ABHD16A	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). (558 aa)
	CCHCR1	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. (871 aa)
	OR12D3	Olfactory receptor 12D3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	BTNL2	Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family. (482 aa)
	C10orf105	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105. (133 aa)
	TSBP1	Testis expressed basic protein 1. (563 aa)
	ZFP57	Zinc finger protein 57 homolog; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant [...] (536 aa)
	OR10C1	Olfactory receptor 10C1; Odorant receptor. (312 aa)
	LY6G6F-LY6G6D	Lymphocyte antigen 6 complex locus protein G6d. (382 aa)
	OR2H2	Olfactory receptor 2H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (312 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD16A	C6orf47	ENSP00000379282	ENSP00000365076	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.	0.488
ABHD16A	GPANK1	ENSP00000379282	ENSP00000365071	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	G-patch domain and ankyrin repeats 1.	0.659
ABHD16A	LST1	ENSP00000379282	ENSP00000365261	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.	0.762
ABHD16A	PRRC2A	ENSP00000379282	ENSP00000365201	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing.	0.755
ABHD16A	ZBTB12	ENSP00000379282	ENSP00000364677	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	Zinc finger and BTB domain-containing protein 12; May be involved in transcriptional regulation.	0.829
BTNL2	TSBP1	ENSP00000390613	ENSP00000415517	Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family.	Testis expressed basic protein 1.	0.698
BTNL2	TTC32	ENSP00000390613	ENSP00000333018	Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family.	Tetratricopeptide repeat domain 32.	0.508
C10orf105	RNF39	ENSP00000403151	ENSP00000244360	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance.	0.578
C6orf136	GNL1	ENSP00000293604	ENSP00000365806	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136.	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	0.521
C6orf136	NRM	ENSP00000293604	ENSP00000259953	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136.	Nurim.	0.529
C6orf136	TCF19	ENSP00000293604	ENSP00000365433	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136.	Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.	0.470
C6orf47	ABHD16A	ENSP00000365076	ENSP00000379282	Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.	Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G).	0.488
C6orf47	GPANK1	ENSP00000365076	ENSP00000365071	Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.	G-patch domain and ankyrin repeats 1.	0.669
C6orf47	PRRC2A	ENSP00000365076	ENSP00000365201	Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.	Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing.	0.453
CCDC116	GNL1	ENSP00000292779	ENSP00000365806	Coiled-coil domain containing 116.	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	0.785
CCHCR1	GNL1	ENSP00000379566	ENSP00000365806	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.	Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.	0.416
CCHCR1	PSORS1C1	ENSP00000379566	ENSP00000259881	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.	Psoriasis susceptibility 1 candidate 1.	0.645
CCHCR1	PSORS1C2	ENSP00000379566	ENSP00000259845	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.	Psoriasis susceptibility 1 candidate 2.	0.778
CCHCR1	RNF39	ENSP00000379566	ENSP00000244360	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.	RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance.	0.491
CCHCR1	TCF19	ENSP00000379566	ENSP00000365433	Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.	Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.	0.799