STRINGSTRING
MAGEA9 MAGEA9 MAGEA10 MAGEA10 CTAG2 CTAG2 CT55 CT55 GMCL1 GMCL1 ZNF117 ZNF117 MAGEC1 MAGEC1 XAGE2 XAGE2 PAGE5 PAGE5 SSX3 SSX3 XAGE3 XAGE3 SSX5 SSX5 SAGE1 SAGE1 PRSS50 PRSS50 CTAG1B CTAG1B SS18L1 SS18L1 MAGEA2B MAGEA2B SSX2 SSX2 MAGEA1 MAGEA1 SPANXC SPANXC MAGEA4 MAGEA4 MAGEC2 MAGEC2 CSAG1 CSAG1 DDX43 DDX43 PASD1 PASD1 SPANXD SPANXD SPANXA2 SPANXA2 SPANXA1 SPANXA1 XAGE1A XAGE1A XAGE1B XAGE1B SSX1 SSX1 MAGEB2 MAGEB2 MAGEA12 MAGEA12 SS18L2 SS18L2 SPANXB1 SPANXB1 SPANXN4 SPANXN4 MAGED4B MAGED4B SSX4 SSX4 SSX4B SSX4B CTAG1A CTAG1A MAGED4 MAGED4 ZNF83 ZNF83 MAGEA3 MAGEA3 SSX2B SSX2B MAGEA6 MAGEA6 GAGE1 GAGE1 MAGEA2 MAGEA2 CSAG2 CSAG2 CSAG3 CSAG3 DSE DSE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAGEA9Melanoma-associated antigen 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (315 aa)
MAGEA10Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (369 aa)
CTAG2Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. (210 aa)
CT55Cancer/testis antigen 55. (264 aa)
GMCL1Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). (515 aa)
ZNF117Zinc finger protein 117; May be involved in transcriptional regulation. (483 aa)
MAGEC1Melanoma-associated antigen C1; MAGE family member C1. (1142 aa)
XAGE2X antigen family member 2. (111 aa)
PAGE5PAGE family member 5; Belongs to the GAGE family. (130 aa)
SSX3Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. (188 aa)
XAGE3X antigen family member 3. (111 aa)
SSX5Protein SSX5; Could act as a modulator of transcription. (229 aa)
SAGE1Sarcoma antigen 1. (904 aa)
PRSS50Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. (385 aa)
CTAG1BCancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. (180 aa)
SS18L1Calcium-responsive transactivator; Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is depho [...] (396 aa)
MAGEA2BMelanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] (314 aa)
SSX2SSX family member 2. (223 aa)
MAGEA1Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (309 aa)
SPANXCSperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family. (97 aa)
MAGEA4Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (317 aa)
MAGEC2Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. (373 aa)
CSAG1Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. (78 aa)
DDX43Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43. (648 aa)
PASD1Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed. (773 aa)
SPANXDSperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family. (97 aa)
SPANXA2Sperm protein associated with the nucleus on the X chromosome A; SPANX family member A2; Belongs to the SPAN-X family. (97 aa)
SPANXA1Sperm protein associated with the nucleus, X-linked, family member A1. (97 aa)
XAGE1AX antigen family member 1A. (81 aa)
XAGE1BX antigen family member 1B. (81 aa)
SSX1Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. (188 aa)
MAGEB2Melanoma-associated antigen B2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. (319 aa)
MAGEA12Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. (314 aa)
SS18L2SS18-like protein 2; SS18 like 2. (77 aa)
SPANXB1Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1. (103 aa)
SPANXN4Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family. (99 aa)
MAGED4BMelanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. (757 aa)
SSX4Protein SSX4; Could act as a modulator of transcription. (188 aa)
SSX4BSSX family member 4B. (188 aa)
CTAG1ACancer/testis antigen 1A. (180 aa)
MAGED4MAGE family member D4. (757 aa)
ZNF83Zinc finger protein 83; May be involved in transcriptional regulation. (516 aa)
MAGEA3Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (314 aa)
SSX2BSSX family member 2B. (223 aa)
MAGEA6Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. (314 aa)
GAGE1G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. (117 aa)
MAGEA2MAGE family member A2. (314 aa)
CSAG2Chondrosarcoma-associated gene 2/3 protein; CSAG family member 2. (110 aa)
CSAG3Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. (110 aa)
DSEDermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. (958 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.