STRINGSTRING
MAGEA9 MAGEA9 MAGEA10 MAGEA10 CTAG2 CTAG2 CT55 CT55 MAGEC1 MAGEC1 PAGE5 PAGE5 SAGE1 SAGE1 PRSS50 PRSS50 CTAG1B CTAG1B MAGEA2B MAGEA2B MAGEA1 MAGEA1 SPANXC SPANXC MAGEA4 MAGEA4 MAGEC2 MAGEC2 CSAG1 CSAG1 DDX43 DDX43 PASD1 PASD1 SPANXD SPANXD SPANXA2 SPANXA2 SPANXA1 SPANXA1 MAGEB2 MAGEB2 MAGEA12 MAGEA12 SPANXB1 SPANXB1 SPANXN4 SPANXN4 CTAG1A CTAG1A MAGEA3 MAGEA3 MAGEA6 MAGEA6 GAGE1 GAGE1 MAGEA2 MAGEA2 CSAG2 CSAG2 CSAG3 CSAG3 DSE DSE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAGEA9Melanoma-associated antigen 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (315 aa)
MAGEA10Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (369 aa)
CTAG2Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. (210 aa)
CT55Cancer/testis antigen 55. (264 aa)
MAGEC1Melanoma-associated antigen C1; MAGE family member C1. (1142 aa)
PAGE5PAGE family member 5; Belongs to the GAGE family. (130 aa)
SAGE1Sarcoma antigen 1. (904 aa)
PRSS50Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family. (385 aa)
CTAG1BCancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. (180 aa)
MAGEA2BMelanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] (314 aa)
MAGEA1Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (309 aa)
SPANXCSperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family. (97 aa)
MAGEA4Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (317 aa)
MAGEC2Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. (373 aa)
CSAG1Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. (78 aa)
DDX43Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43. (648 aa)
PASD1Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed. (773 aa)
SPANXDSperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family. (97 aa)
SPANXA2Sperm protein associated with the nucleus on the X chromosome A; SPANX family member A2; Belongs to the SPAN-X family. (97 aa)
SPANXA1Sperm protein associated with the nucleus, X-linked, family member A1. (97 aa)
MAGEB2Melanoma-associated antigen B2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. (319 aa)
MAGEA12Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. (314 aa)
SPANXB1Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1. (103 aa)
SPANXN4Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family. (99 aa)
CTAG1ACancer/testis antigen 1A. (180 aa)
MAGEA3Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (314 aa)
MAGEA6Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. (314 aa)
GAGE1G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. (117 aa)
MAGEA2MAGE family member A2. (314 aa)
CSAG2Chondrosarcoma-associated gene 2/3 protein; CSAG family member 2. (110 aa)
CSAG3Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. (110 aa)
DSEDermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. (958 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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