STRINGSTRING
GPR63 GPR63 AGA AGA RNASE7 RNASE7 ZNF407 ZNF407 RNASE6 RNASE6 FSTL5 FSTL5 KLF7 KLF7 RNASE8 RNASE8 ZNF738 ZNF738 C3orf22 C3orf22 ZNF236 ZNF236 ZADH2 ZADH2 SH2D7 SH2D7 SPDYE4 SPDYE4 KIAA0825 KIAA0825 USP45 USP45 SPATA12 SPATA12 ANG ANG GLYAT GLYAT SPATA31D1 SPATA31D1 FBXO38 FBXO38 MANEA MANEA LRRC27 LRRC27 FBXL4 FBXL4 KLHL32 KLHL32 C9orf50 C9orf50 ZMAT1 ZMAT1 OR5C1 OR5C1 CLPSL1 CLPSL1 C22orf42 C22orf42 RNASE13 RNASE13 SHISAL2B SHISAL2B FAXC FAXC CHD2 CHD2 CC2D2B CC2D2B C4orf51 C4orf51 DCD DCD C1orf167 C1orf167 C21orf62 C21orf62 RNASET2 RNASET2 AMER2 AMER2 NKAIN3 NKAIN3 RNH1 RNH1 C12orf56 C12orf56 RNASE12 RNASE12 RNASE11 RNASE11 RNASE4 RNASE4 SMIM21 SMIM21 TSHZ1 TSHZ1 ZNF699 ZNF699 ANKRD62 ANKRD62 ZNF836 ZNF836 SMIM17 SMIM17 GGTLC3 GGTLC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR63Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function. (419 aa)
AGAN(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. (346 aa)
RNASE7Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Belongs to the pancreatic ribonuclease family. (156 aa)
ZNF407Zinc finger protein 407; May be involved in transcriptional regulation. (2248 aa)
RNASE6Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram- negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. (150 aa)
FSTL5Follistatin-related protein 5; Follistatin like 5. (847 aa)
KLF7Krueppel-like factor 7; Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin. (302 aa)
RNASE8Ribonuclease 8; Has a low ribonuclease activity. (154 aa)
ZNF738Protein ZNF738; May be involved in transcriptional regulation. (137 aa)
C3orf22Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22. (141 aa)
ZNF236Zinc finger protein 236; May be involved in transcriptional regulation. (1847 aa)
ZADH2Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. (377 aa)
SH2D7SH2 domain containing 7. (451 aa)
SPDYE4Speedy protein E4; speedy/RINGO cell cycle regulator family member E4; Belongs to the Speedy/Ringo family. (237 aa)
KIAA0825Uncharacterized protein KIAA0825; KIAA0825. (324 aa)
USP45Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. (814 aa)
SPATA12Spermatogenesis-associated protein 12; Spermatogenesis associated 12. (190 aa)
ANGAngiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. (147 aa)
GLYATGlycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N- acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. (296 aa)
SPATA31D1Spermatogenesis-associated protein 31D1; May play a role in spermatogenesis; Belongs to the SPATA31 family. (1576 aa)
FBXO38F-box only protein 38; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without [...] (1188 aa)
MANEAGlycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. (462 aa)
LRRC27Leucine-rich repeat-containing protein 27; Leucine rich repeat containing 27. (530 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
KLHL32Kelch-like protein 32; Kelch like family member 32. (620 aa)
C9orf50Uncharacterized protein C9orf50; Chromosome 9 open reading frame 50. (431 aa)
ZMAT1Zinc finger matrin-type 1. (638 aa)
OR5C1Olfactory receptor 5C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (320 aa)
CLPSL1Colipase-like protein 1; Colipase like 1; Belongs to the colipase family. (121 aa)
C22orf42Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42. (251 aa)
RNASE13Probable inactive ribonuclease-like protein 13; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family. (156 aa)
SHISAL2BProtein shisa-like-2B; Shisa like 2B. (160 aa)
FAXCFailed axon connections homolog; May play a role in axonal development. (409 aa)
CHD2Chromodomain-helicase-DNA-binding protein 2; DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). (1828 aa)
CC2D2BProtein CC2D2B; Coiled-coil and C2 domain containing 2B. (401 aa)
C4orf51Uncharacterized protein C4orf51; Chromosome 4 open reading frame 51. (202 aa)
DCDSurvival-promoting peptide; DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C- terminal side of Arg and, to a lesser extent, Lys residues. (121 aa)
C1orf167Uncharacterized protein C1orf167; Chromosome 1 open reading frame 167. (1468 aa)
C21orf62Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62. (219 aa)
RNASET2Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. Belongs to the RNase T2 family. (256 aa)
AMER2APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex; Belongs to the Amer family. (671 aa)
NKAIN3Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Sodium/potassium transporting ATPase interacting 3; Belongs to the NKAIN family. (197 aa)
RNH1Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. (461 aa)
C12orf56Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56. (622 aa)
RNASE12Probable inactive ribonuclease-like protein 12; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family. (147 aa)
RNASE11Ribonuclease A family member 11. (199 aa)
RNASE4Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (147 aa)
SMIM21Small integral membrane protein 21. (101 aa)
TSHZ1Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. (1077 aa)
ZNF699Zinc finger protein 699; May be involved in transcriptional regulation. (642 aa)
ANKRD62Ankyrin repeat domain 62. (917 aa)
ZNF836Zinc finger protein 836; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (936 aa)
SMIM17Small integral membrane protein 17. (118 aa)
GGTLC3Gamma-glutamyltransferase light chain family member 3. (225 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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