STRINGSTRING
RHOXF1 RHOXF1 ZNF432 ZNF432 TSHZ3 TSHZ3 ZNF350 ZNF350 TRIM28 TRIM28 ZNF225 ZNF225 ZFP14 ZFP14 ZNF614 ZNF614 ZNF773 ZNF773 ZNF256 ZNF256 DDAH1 DDAH1 ZNF250 ZNF250 ZNF585A ZNF585A ZNF382 ZNF382 ZNF613 ZNF613 ZNF502 ZNF502 ZNF582 ZNF582 ZFP28 ZFP28 ZNF439 ZNF439 ZNF471 ZNF471 ZNF554 ZNF554 ZNF84 ZNF84 ZNF470 ZNF470 ZNF568 ZNF568 ZNF548 ZNF548 ZNF93 ZNF93 ZNF189 ZNF189 ZFP30 ZFP30 ZNF136 ZNF136 ZNF774 ZNF774 ZNF649 ZNF649 ZNF140 ZNF140 ZNF44 ZNF44 ZNF790 ZNF790 ZNF816 ZNF816 ZNF441 ZNF441 SMARCAD1 SMARCAD1 ZNF808 ZNF808 ZNF528 ZNF528 KHDC4 KHDC4 ZNF549 ZNF549 ZNF81 ZNF81 ZNF566 ZNF566 ZNF605 ZNF605 ZNF248 ZNF248 ZNF765 ZNF765 ZNF665 ZNF665 ZNF682 ZNF682 ZNF610 ZNF610 ZNF385B ZNF385B ZNF419 ZNF419 ZNF844 ZNF844 ZNF28 ZNF28 ZNF234 ZNF234 ZNF347 ZNF347 ZNF799 ZNF799 ZNF713 ZNF713 ZNF525 ZNF525 C1orf52 C1orf52 ZNF829 ZNF829 ZNF674 ZNF674 ZNF260 ZNF260 ZNF345 ZNF345 ZFP82 ZFP82 ZNF585B ZNF585B ZNF611 ZNF611 ZNF667 ZNF667 ZNF415 ZNF415 ZNF135 ZNF135 ZNF701 ZNF701 ZNF550 ZNF550 ZNF529 ZNF529 ZNF570 ZNF570 ZNF559 ZNF559 ZNF677 ZNF677 ZNF329 ZNF329 ZNF468 ZNF468 ZNF615 ZNF615 ZIK1 ZIK1 ZNF8 ZNF8 ZNF283 ZNF283 ZNF793 ZNF793 ZBTB3 ZBTB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOXF1Rhox homeobox family member 1; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. (184 aa)
ZNF432Zinc finger protein 432; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (652 aa)
TSHZ3Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] (1081 aa)
ZNF350Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3. (532 aa)
TRIM28Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
ZNF225Zinc finger protein 225; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (706 aa)
ZFP14Zinc finger protein 14 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (533 aa)
ZNF614Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (585 aa)
ZNF773Zinc finger protein 773; May be involved in transcriptional regulation. (442 aa)
ZNF256Zinc finger protein 256; Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Belongs to the krueppel C2H2-type zinc-finger protein family. (627 aa)
DDAH1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. (285 aa)
ZNF250Zinc finger protein 250; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (560 aa)
ZNF585AZinc finger protein 585A; May be involved in transcriptional regulation. (769 aa)
ZNF382Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. (550 aa)
ZNF613Zinc finger protein 613; May be involved in transcriptional regulation. (617 aa)
ZNF502Zinc finger protein 502; May be involved in transcriptional regulation. (544 aa)
ZNF582Zinc finger protein 582; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (517 aa)
ZFP28Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development. (868 aa)
ZNF439Zinc finger protein 439; May be involved in transcriptional regulation. (499 aa)
ZNF471Zinc finger protein 471; May be involved in transcriptional regulation. (626 aa)
ZNF554Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (538 aa)
ZNF84Zinc finger protein 84; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (738 aa)
ZNF470Zinc finger protein 470; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (717 aa)
ZNF568Zinc finger protein 568; Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance p [...] (644 aa)
ZNF548Zinc finger protein 548; May be involved in transcriptional regulation. (545 aa)
ZNF93Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...] (620 aa)
ZNF189Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (626 aa)
ZFP30Zinc finger protein 30 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (519 aa)
ZNF136Zinc finger protein 136; May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain; Belongs to the krueppel C2H2-type zinc-finger protein family. (540 aa)
ZNF774Zinc finger protein 774; May be involved in transcriptional regulation. (483 aa)
ZNF649Zinc finger protein 649; Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways. Belongs to the krueppel C2H2-type zinc-finger protein family. (505 aa)
ZNF140Zinc finger protein 140; May be involved in transcriptional regulation as a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family. (457 aa)
ZNF44Zinc finger protein 44; May be involved in transcriptional regulation. (663 aa)
ZNF790Zinc finger protein 790; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (636 aa)
ZNF816Zinc finger protein 816; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (651 aa)
ZNF441Zinc finger protein 441; May be involved in transcriptional regulation. (693 aa)
SMARCAD1ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...] (1028 aa)
ZNF808Zinc finger protein 808; May be involved in transcriptional regulation. (903 aa)
ZNF528Zinc finger protein 528; May be involved in transcriptional regulation. (628 aa)
KHDC4KH homology domain-containing protein 4; RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches ; Belongs to the KHDC4 family. (614 aa)
ZNF549Zinc finger protein 549; May be involved in transcriptional regulation. (640 aa)
ZNF81Zinc finger protein 81; May be involved in transcriptional regulation. (661 aa)
ZNF566Zinc finger protein 566; May be involved in transcriptional regulation. (419 aa)
ZNF605Zinc finger protein 605; May be involved in transcriptional regulation. (672 aa)
ZNF248Zinc finger protein 248; May be involved in transcriptional regulation. (579 aa)
ZNF765Zinc finger protein 765; May be involved in transcriptional regulation. (523 aa)
ZNF665Zinc finger protein 665; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (678 aa)
ZNF682Zinc finger protein 682; May be involved in transcriptional regulation. (498 aa)
ZNF610Zinc finger protein 610; May be involved in transcriptional regulation. (462 aa)
ZNF385BZinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. (486 aa)
ZNF419Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (511 aa)
ZNF844Zinc finger protein 844; May be involved in transcriptional regulation. (666 aa)
ZNF28Zinc finger protein 28; May be involved in transcriptional regulation. (718 aa)
ZNF234Zinc finger protein 234; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (700 aa)
ZNF347Zinc finger protein 347; May be involved in transcriptional regulation. (840 aa)
ZNF799Zinc finger protein 799; May be involved in transcriptional regulation. (643 aa)
ZNF713Zinc finger protein 713; May be involved in transcriptional regulation. (443 aa)
ZNF525Zinc finger protein 525. (479 aa)
C1orf52UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. (182 aa)
ZNF829Zinc finger protein 829; May be involved in transcriptional regulation. (513 aa)
ZNF674Zinc finger protein 674; May be involved in transcriptional regulation. (581 aa)
ZNF260Zinc finger protein 260; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity). (412 aa)
ZNF345Zinc finger protein 345; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (488 aa)
ZFP82Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (532 aa)
ZNF585BZinc finger protein 585B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (769 aa)
ZNF611Zinc finger protein 611; May be involved in transcriptional regulation. (705 aa)
ZNF667Zinc finger protein 667; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (610 aa)
ZNF415Zinc finger protein 415; Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53. (555 aa)
ZNF135Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (682 aa)
ZNF701Zinc finger protein 701; May be involved in transcriptional regulation. (531 aa)
ZNF550Zinc finger protein 550; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (422 aa)
ZNF529Zinc finger protein 529; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (563 aa)
ZNF570Zinc finger protein 570; May be involved in transcriptional regulation. (592 aa)
ZNF559Zinc finger protein 559; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (602 aa)
ZNF677Zinc finger protein 677; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (584 aa)
ZNF329Zinc finger protein 329; May be involved in transcriptional regulation. (541 aa)
ZNF468Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (522 aa)
ZNF615Zinc finger protein 615; May be involved in transcriptional regulation. (742 aa)
ZIK1Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor. (487 aa)
ZNF8Zinc finger protein 8; Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. Belongs to the krueppel C2H2-type zinc-finger protein family. (575 aa)
ZNF283Zinc finger protein 283; May be involved in transcriptional regulation. (679 aa)
ZNF793Zinc finger protein 793; May be involved in transcriptional regulation. (406 aa)
ZBTB3Zinc finger and BTB domain-containing protein 3; May be involved in transcriptional regulation. (574 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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