STRINGSTRING
ZNF350 ZNF350 TRIM28 TRIM28 ZNF613 ZNF613 ZNF93 ZNF93 ZNF136 ZNF136 ZNF649 ZNF649 ZNF44 ZNF44 ZNF816 ZNF816 SMARCAD1 SMARCAD1 ZNF808 ZNF808 ZNF28 ZNF28 ZNF799 ZNF799 ZNF525 ZNF525 ZNF611 ZNF611 ZNF701 ZNF701 ZNF468 ZNF468
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF350Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3. (532 aa)
TRIM28Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
ZNF613Zinc finger protein 613; May be involved in transcriptional regulation. (617 aa)
ZNF93Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...] (620 aa)
ZNF136Zinc finger protein 136; May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain; Belongs to the krueppel C2H2-type zinc-finger protein family. (540 aa)
ZNF649Zinc finger protein 649; Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways. Belongs to the krueppel C2H2-type zinc-finger protein family. (505 aa)
ZNF44Zinc finger protein 44; May be involved in transcriptional regulation. (663 aa)
ZNF816Zinc finger protein 816; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (651 aa)
SMARCAD1ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...] (1028 aa)
ZNF808Zinc finger protein 808; May be involved in transcriptional regulation. (903 aa)
ZNF28Zinc finger protein 28; May be involved in transcriptional regulation. (718 aa)
ZNF799Zinc finger protein 799; May be involved in transcriptional regulation. (643 aa)
ZNF525Zinc finger protein 525. (479 aa)
ZNF611Zinc finger protein 611; May be involved in transcriptional regulation. (705 aa)
ZNF701Zinc finger protein 701; May be involved in transcriptional regulation. (531 aa)
ZNF468Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (522 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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