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| | ARHGEF5 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] (1597 aa) |
| | PTPN18 | Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. (460 aa) |
| | CPNE5 | Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes ; Belongs to the copine family. (593 aa) |
| | PCNX2 | Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Belongs to the pecanex family. (2137 aa) |
| | OR13C9 | Olfactory receptor 13C9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | ANKRD13A | Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. (590 aa) |
| | PTPN4 | Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membran [...] (926 aa) |
| | GAREM1 | GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Belongs to the GAREM family. (876 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. (802 aa) |
| | RNF44 | Ring finger protein 44. (432 aa) |
| | TAAR1 | Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained spe [...] (339 aa) |
| | FGD5 | FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. (1462 aa) |
| | C1orf74 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. (269 aa) |
| | SERPINI1 | Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). (410 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF). (1519 aa) |
| | ECEL1 | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. (775 aa) |
| | CSDC2 | Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). (153 aa) |
| | PWWP2A | PWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. (755 aa) |
| | MORN4 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa) |
| | SLC37A2 | Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. (505 aa) |
| | C2orf69 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. (385 aa) |
| | FAM71C | Protein FAM71C; Family with sequence similarity 71 member C. (241 aa) |
| | OR13D1 | Olfactory receptor 13D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (346 aa) |
| | C11orf16 | Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16. (467 aa) |
| | ZNF620 | Zinc finger protein 620; May be involved in transcriptional regulation. (422 aa) |
| | OR56B1 | Olfactory receptor 56B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa) |
| | TTC39C | Tetratricopeptide repeat domain 39C. (583 aa) |
| | GLTPD2 | Glycolipid transfer protein domain containing 2; Belongs to the GLTP family. (291 aa) |
| | NXPH3 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family. (252 aa) |
| | VSTM4 | V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L- VGCC) currents in retinal photoreceptors. (320 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (725 aa) |
| | FAM25A | Protein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family. (89 aa) |
| | PAPLN | Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family. (1251 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26; Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. (871 aa) |
| | EML6 | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (1958 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2. (841 aa) |
| | AIF1L | Allograft inflammatory factor 1-like; Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. (176 aa) |
| | C2orf72 | Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72. (295 aa) |
| | AGAP5 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa) |
| | TMEM273 | Transmembrane protein 273. (129 aa) |
| | FRMPD2 | FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). (1309 aa) |
| | SUSD1 | Sushi domain containing 1. (757 aa) |
| | SYT15 | Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. (421 aa) |
| | PTPN20 | Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (420 aa) |
| | ZNF485 | Zinc finger protein 485; May be involved in transcriptional regulation. (441 aa) |
| | EPB41L4B | Band 4.1-like protein 4B; Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid- induced cell differentiation. (900 aa) |
| | NIPSNAP3B | Nipsnap homolog 3B; Belongs to the NipSnap family. (247 aa) |
| | NIPSNAP3A | Nipsnap homolog 3A; Belongs to the NipSnap family. (247 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. (961 aa) |
| | ARHGEF35 | Rho guanine nucleotide exchange factor 35. (484 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. (709 aa) |
| | PARM1 | Prostate androgen-regulated mucin-like protein 1; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. (310 aa) |
| | TMEM74B | Transmembrane protein 74B. (256 aa) |
| | CTAGE1 | cTAGE family member 2; Cutaneous T cell lymphoma-associated antigen 1. (745 aa) |
| | NREP | Neuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. (112 aa) |
| | PLEKHG6 | Pleckstrin homology domain-containing family G member 6; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. (790 aa) |
| | C19orf38 | Protein HIDE1; Chromosome 19 open reading frame 38. (230 aa) |
| | GAREM2 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family. (874 aa) |
| | SDK1 | Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. (2213 aa) |
| | HMSD | Serpin-like protein HMSD; Putative serine protease inhibitor. (139 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor. (870 aa) |
| | AGAP9 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 9. (658 aa) |
| | AGAP4 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (663 aa) |
| | CTAGE9 | CTAGE family member 9. (777 aa) |
| | FRMD5 | FERM domain-containing protein 5; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation. (570 aa) |
| | FBXO10 | F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. (956 aa) |
| | TCAF2 | TRPM8 channel-associated factor 2; [Isoform 2]: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. (919 aa) |
| | TMEM169 | Transmembrane protein 169. (297 aa) |
| | OR4A47 | Olfactory receptor 4A47; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa) |
| | ZNF732 | Zinc finger protein 732; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (585 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor. (777 aa) |
| | LSAMP | Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family. (338 aa) |
| | CTAGE4 | cTAGE family member 4; Tumor-associated antigen; Belongs to the cTAGE family. (777 aa) |
| | TRNP1 | TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity). (227 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves. (1368 aa) |
| | OR13C2 | Olfactory receptor 13C2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | FRMPD1 | FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. (1578 aa) |
| | SPIC | Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family. (248 aa) |
| | OR11H12 | Olfactory receptor 11H12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | ZNF488 | Zinc finger protein 488; Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling- activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury. (340 aa) |
| | MIA | Melanoma-derived growth regulatory protein; Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas; Belongs to the MIA/OTOR family. (131 aa) |
| | CTAGE15 | CTAGE family member 15. (777 aa) |
| | CTAGE6 | CTAGE family member 6. (777 aa) |
| | LOC102724488 | Uncharacterized protein. (444 aa) |
| | ANTXRL | Anthrax toxin receptor-like; ANTXR like. (631 aa) |
| | SPATS2L | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. (588 aa) |
| | ARHGEF18 | Rho/Rac guanine nucleotide exchange factor 18. (1173 aa) |
| | FTCDNL1 | Formiminotransferase cyclodeaminase N-terminal like. (147 aa) |
| | EPB41L4A | Erythrocyte membrane protein band 4.1 like 4A. (686 aa) |
| | FAM25C | Family with sequence similarity 25 member C. (89 aa) |
| | ENSP00000489910 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (582 aa) |
| | TCAF2C | TRPM8 channel associated factor 2C. (712 aa) |
| | NYAP2 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. (653 aa) |
| | PLEKHG7 | Pleckstrin homology and RhoGEF domain containing G7. (379 aa) |
| | OR2V2 | Olfactory receptor 2V2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (315 aa) |
| | ASAH2B | Putative inactive neutral ceramidase B; N-acylsphingosine amidohydrolase 2B. (165 aa) |
| | AKR1C8P | Aldo-keto reductase family 1 member C8, pseudogene. (326 aa) |
| | TRIM51GP | Tripartite motif-containing 51G, pseudogene. (452 aa) |
| | ARHGEF18-2 | Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumf [...] (1089 aa) |
| | ENSP00000500339 | Uncharacterized protein. (444 aa) |
| | AGAP6 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa) |
