STRINGSTRING
PTPN18 PTPN18 CPNE5 CPNE5 PCNX2 PCNX2 OR13C9 OR13C9 ANKRD13A ANKRD13A PTPN4 PTPN4 RNF44 RNF44 TAAR1 TAAR1 C1orf74 C1orf74 SERPINI1 SERPINI1 CSDC2 CSDC2 PWWP2A PWWP2A MORN4 MORN4 SLC37A2 SLC37A2 C2orf69 C2orf69 FAM71C FAM71C OR13D1 OR13D1 C11orf16 C11orf16 ZNF620 ZNF620 OR56B1 OR56B1 TTC39C TTC39C GLTPD2 GLTPD2 VSTM4 VSTM4 FAM25A FAM25A EML6 EML6 AGAP5 AGAP5 TMEM273 TMEM273 FRMPD2 FRMPD2 SUSD1 SUSD1 SYT15 SYT15 PTPN20 PTPN20 NIPSNAP3B NIPSNAP3B NIPSNAP3A NIPSNAP3A PARM1 PARM1 NREP NREP HMSD HMSD AGAP9 AGAP9 AGAP4 AGAP4 FRMD5 FRMD5 FBXO10 FBXO10 ZNF732 ZNF732 LSAMP LSAMP OR13C2 OR13C2 FRMPD1 FRMPD1 SPIC SPIC ZNF488 ZNF488 LOC102724488 LOC102724488 ANTXRL ANTXRL SPATS2L SPATS2L FTCDNL1 FTCDNL1 EPB41L4A EPB41L4A FAM25C FAM25C ENSP00000489910 ENSP00000489910 NYAP2 NYAP2 ASAH2B ASAH2B AKR1C8P AKR1C8P AGAP6 AGAP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN18Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. (460 aa)
CPNE5Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes ; Belongs to the copine family. (593 aa)
PCNX2Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Belongs to the pecanex family. (2137 aa)
OR13C9Olfactory receptor 13C9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa)
ANKRD13AAnkyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. (590 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membran [...] (926 aa)
RNF44Ring finger protein 44. (432 aa)
TAAR1Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained spe [...] (339 aa)
C1orf74UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. (269 aa)
SERPINI1Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). (410 aa)
CSDC2Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). (153 aa)
PWWP2APWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. (755 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
SLC37A2Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. (505 aa)
C2orf69UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. (385 aa)
FAM71CProtein FAM71C; Family with sequence similarity 71 member C. (241 aa)
OR13D1Olfactory receptor 13D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (346 aa)
C11orf16Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16. (467 aa)
ZNF620Zinc finger protein 620; May be involved in transcriptional regulation. (422 aa)
OR56B1Olfactory receptor 56B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa)
TTC39CTetratricopeptide repeat domain 39C. (583 aa)
GLTPD2Glycolipid transfer protein domain containing 2; Belongs to the GLTP family. (291 aa)
VSTM4V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L- VGCC) currents in retinal photoreceptors. (320 aa)
FAM25AProtein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family. (89 aa)
EML6Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (1958 aa)
AGAP5Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa)
TMEM273Transmembrane protein 273. (129 aa)
FRMPD2FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). (1309 aa)
SUSD1Sushi domain containing 1. (757 aa)
SYT15Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. (421 aa)
PTPN20Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (420 aa)
NIPSNAP3BNipsnap homolog 3B; Belongs to the NipSnap family. (247 aa)
NIPSNAP3ANipsnap homolog 3A; Belongs to the NipSnap family. (247 aa)
PARM1Prostate androgen-regulated mucin-like protein 1; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. (310 aa)
NREPNeuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. (112 aa)
HMSDSerpin-like protein HMSD; Putative serine protease inhibitor. (139 aa)
AGAP9ArfGAP with GTPase domain, ankyrin repeat and PH domain 9. (658 aa)
AGAP4Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (663 aa)
FRMD5FERM domain-containing protein 5; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation. (570 aa)
FBXO10F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. (956 aa)
ZNF732Zinc finger protein 732; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (585 aa)
LSAMPLimbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family. (338 aa)
OR13C2Olfactory receptor 13C2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (318 aa)
FRMPD1FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. (1578 aa)
SPICTranscription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family. (248 aa)
ZNF488Zinc finger protein 488; Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling- activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury. (340 aa)
LOC102724488Uncharacterized protein. (444 aa)
ANTXRLAnthrax toxin receptor-like; ANTXR like. (631 aa)
SPATS2LSPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. (588 aa)
FTCDNL1Formiminotransferase cyclodeaminase N-terminal like. (147 aa)
EPB41L4AErythrocyte membrane protein band 4.1 like 4A. (686 aa)
FAM25CFamily with sequence similarity 25 member C. (89 aa)
ENSP00000489910Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (582 aa)
NYAP2Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. (653 aa)
ASAH2BPutative inactive neutral ceramidase B; N-acylsphingosine amidohydrolase 2B. (165 aa)
AKR1C8PAldo-keto reductase family 1 member C8, pseudogene. (326 aa)
AGAP6Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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