(13 nodes) Mixed, incl. Putative GTP-ase activating proteins for the small GTPase, ARF, and Anthrax toxin receptor, extracellular domain network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPN18	Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. (460 aa)
	ZNF620	Zinc finger protein 620; May be involved in transcriptional regulation. (422 aa)
	FAM25A	Protein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family. (89 aa)
	AGAP5	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa)
	TMEM273	Transmembrane protein 273. (129 aa)
	FRMPD2	FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). (1309 aa)
	SYT15	Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. (421 aa)
	PTPN20	Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (420 aa)
	AGAP9	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9. (658 aa)
	AGAP4	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (663 aa)
	LOC102724488	Uncharacterized protein. (444 aa)
	ANTXRL	Anthrax toxin receptor-like; ANTXR like. (631 aa)
	AGAP6	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family. (686 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP4	AGAP5	ENSP00000392513	ENSP00000363207	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.538
AGAP4	AGAP6	ENSP00000392513	ENSP00000500374	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.925
AGAP5	AGAP4	ENSP00000363207	ENSP00000392513	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.538
AGAP5	AGAP6	ENSP00000363207	ENSP00000500374	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.531
AGAP5	AGAP9	ENSP00000363207	ENSP00000392206	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	0.445
AGAP6	AGAP4	ENSP00000500374	ENSP00000392513	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.925
AGAP6	AGAP5	ENSP00000500374	ENSP00000363207	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.531
AGAP6	AGAP9	ENSP00000500374	ENSP00000392206	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	0.468
AGAP6	ANTXRL	ENSP00000500374	ENSP00000480615	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Anthrax toxin receptor-like; ANTXR like.	0.509
AGAP6	FAM25A	ENSP00000500374	ENSP00000342790	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Protein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family.	0.480
AGAP6	FRMPD2	ENSP00000500374	ENSP00000363317	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).	0.442
AGAP6	LOC102724488	ENSP00000500374	ENSP00000478933	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Uncharacterized protein.	0.401
AGAP6	TMEM273	ENSP00000500374	ENSP00000363268	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Transmembrane protein 273.	0.448
AGAP6	ZNF620	ENSP00000500374	ENSP00000322265	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	Zinc finger protein 620; May be involved in transcriptional regulation.	0.474
AGAP9	AGAP5	ENSP00000392206	ENSP00000363207	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.445
AGAP9	AGAP6	ENSP00000392206	ENSP00000500374	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.468
AGAP9	ANTXRL	ENSP00000392206	ENSP00000480615	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	Anthrax toxin receptor-like; ANTXR like.	0.543
AGAP9	FAM25A	ENSP00000392206	ENSP00000342790	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	Protein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family.	0.519
ANTXRL	AGAP6	ENSP00000480615	ENSP00000500374	Anthrax toxin receptor-like; ANTXR like.	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.	0.509
ANTXRL	AGAP9	ENSP00000480615	ENSP00000392206	Anthrax toxin receptor-like; ANTXR like.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.	0.543