16 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CIB3	Calcium and integrin binding family member 3. (187 aa)
	FRRS1	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family. (626 aa)
	KLHL26	Kelch-like protein 26; Kelch like family member 26. (615 aa)
	TSPAN5	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Belongs to the tetraspanin (TM4SF) family. (268 aa)
	ODF3L2	Outer dense fiber of sperm tails 3 like 2. (289 aa)
	ERICH3	Glutamate-rich protein 3; Glutamate rich 3. (1530 aa)
	C14orf28	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28. (310 aa)
	KLHL28	Kelch-like protein 28; Kelch like family member 28. (585 aa)
	KLHL14	Kelch-like protein 14; Kelch like family member 14. (628 aa)
	IPP	Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton. (584 aa)
	CYB561A3	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity). (263 aa)
	CYB561D2	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. (222 aa)
	CYB561	Cytochrome b561; Secretory vesicle-specific electron transport protein. (258 aa)
	M0QYV0_HUMAN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (167 aa)
	ENSP00000492889	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (314 aa)
	OR2A12	Olfactory receptor 2A12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (310 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C14orf28	KLHL28	ENSP00000326846	ENSP00000347193	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	Kelch-like protein 28; Kelch like family member 28.	0.650
CIB3	ERICH3	ENSP00000269878	ENSP00000322609	Calcium and integrin binding family member 3.	Glutamate-rich protein 3; Glutamate rich 3.	0.432
CIB3	KLHL26	ENSP00000269878	ENSP00000300976	Calcium and integrin binding family member 3.	Kelch-like protein 26; Kelch like family member 26.	0.517
CIB3	ODF3L2	ENSP00000269878	ENSP00000318029	Calcium and integrin binding family member 3.	Outer dense fiber of sperm tails 3 like 2.	0.521
CYB561	CYB561D2	ENSP00000464215	ENSP00000391209	Cytochrome b561; Secretory vesicle-specific electron transport protein.	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	0.548
CYB561	FRRS1	ENSP00000464215	ENSP00000287474	Cytochrome b561; Secretory vesicle-specific electron transport protein.	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	0.956
CYB561A3	CYB561D2	ENSP00000389745	ENSP00000391209	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	0.581
CYB561A3	FRRS1	ENSP00000389745	ENSP00000287474	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	0.478
CYB561A3	IPP	ENSP00000389745	ENSP00000379739	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton.	0.559
CYB561D2	CYB561	ENSP00000391209	ENSP00000464215	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	Cytochrome b561; Secretory vesicle-specific electron transport protein.	0.548
CYB561D2	CYB561A3	ENSP00000391209	ENSP00000389745	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	0.581
CYB561D2	FRRS1	ENSP00000391209	ENSP00000287474	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	0.642
CYB561D2	M0QYV0_HUMAN	ENSP00000391209	ENSP00000470087	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.509
ERICH3	CIB3	ENSP00000322609	ENSP00000269878	Glutamate-rich protein 3; Glutamate rich 3.	Calcium and integrin binding family member 3.	0.432
ERICH3	KLHL26	ENSP00000322609	ENSP00000300976	Glutamate-rich protein 3; Glutamate rich 3.	Kelch-like protein 26; Kelch like family member 26.	0.566
ERICH3	ODF3L2	ENSP00000322609	ENSP00000318029	Glutamate-rich protein 3; Glutamate rich 3.	Outer dense fiber of sperm tails 3 like 2.	0.541
ERICH3	TSPAN5	ENSP00000322609	ENSP00000307701	Glutamate-rich protein 3; Glutamate rich 3.	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Belongs to the tetraspanin (TM4SF) family.	0.742
FRRS1	CYB561	ENSP00000287474	ENSP00000464215	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	Cytochrome b561; Secretory vesicle-specific electron transport protein.	0.956
FRRS1	CYB561A3	ENSP00000287474	ENSP00000389745	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	0.478
FRRS1	CYB561D2	ENSP00000287474	ENSP00000391209	Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.	Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.	0.642