6 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPIDR	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. (915 aa)
	RHEX	Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation. (172 aa)
	ZNF736	Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (427 aa)
	FIGNL1	Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic (By similarity); Belongs to the AAA ATPase family. (674 aa)
	ZNF679	Zinc finger protein 679; May be involved in transcriptional regulation. (411 aa)
	TRIM60	Tripartite motif containing 60; Belongs to the TRIM/RBCC family. (471 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FIGNL1	RHEX	ENSP00000410811	ENSP00000356093	Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic (By similarity); Belongs to the AAA ATPase family.	Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation.	0.467
FIGNL1	SPIDR	ENSP00000410811	ENSP00000297423	Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic (By similarity); Belongs to the AAA ATPase family.	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	0.870
RHEX	FIGNL1	ENSP00000356093	ENSP00000410811	Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation.	Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic (By similarity); Belongs to the AAA ATPase family.	0.467
SPIDR	FIGNL1	ENSP00000297423	ENSP00000410811	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic (By similarity); Belongs to the AAA ATPase family.	0.870
SPIDR	TRIM60	ENSP00000297423	ENSP00000497401	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	0.406
SPIDR	ZNF679	ENSP00000297423	ENSP00000416809	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	Zinc finger protein 679; May be involved in transcriptional regulation.	0.454
SPIDR	ZNF736	ENSP00000297423	ENSP00000400852	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.429
TRIM60	SPIDR	ENSP00000497401	ENSP00000297423	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	0.406
TRIM60	ZNF679	ENSP00000497401	ENSP00000416809	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	Zinc finger protein 679; May be involved in transcriptional regulation.	0.517
TRIM60	ZNF736	ENSP00000497401	ENSP00000400852	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.608
ZNF679	SPIDR	ENSP00000416809	ENSP00000297423	Zinc finger protein 679; May be involved in transcriptional regulation.	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	0.454
ZNF679	TRIM60	ENSP00000416809	ENSP00000497401	Zinc finger protein 679; May be involved in transcriptional regulation.	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	0.517
ZNF736	SPIDR	ENSP00000400852	ENSP00000297423	Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	0.429
ZNF736	TRIM60	ENSP00000400852	ENSP00000497401	Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	Tripartite motif containing 60; Belongs to the TRIM/RBCC family.	0.608