(6 nodes) Mixed, incl. F-box only protein 25/32, and FGD1-4, C-terminal PH domain network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERICH1	Glutamate-rich protein 1; Glutamate rich 1. (443 aa)
	FGD2	FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). (655 aa)
	KBTBD11	Kelch repeat and BTB domain containing 11. (623 aa)
	FBXO25	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (367 aa)
	ZNF596	Zinc finger protein 596; May be involved in transcriptional regulation. (504 aa)
	TDRP	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family. (198 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERICH1	FBXO25	ENSP00000262109	ENSP00000372274	Glutamate-rich protein 1; Glutamate rich 1.	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	0.581
ERICH1	KBTBD11	ENSP00000262109	ENSP00000321544	Glutamate-rich protein 1; Glutamate rich 1.	Kelch repeat and BTB domain containing 11.	0.434
ERICH1	TDRP	ENSP00000262109	ENSP00000430325	Glutamate-rich protein 1; Glutamate rich 1.	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.561
ERICH1	ZNF596	ENSP00000262109	ENSP00000381613	Glutamate-rich protein 1; Glutamate rich 1.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.605
FBXO25	ERICH1	ENSP00000372274	ENSP00000262109	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Glutamate-rich protein 1; Glutamate rich 1.	0.581
FBXO25	TDRP	ENSP00000372274	ENSP00000430325	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.706
FBXO25	ZNF596	ENSP00000372274	ENSP00000381613	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	Zinc finger protein 596; May be involved in transcriptional regulation.	0.607
FGD2	KBTBD11	ENSP00000274963	ENSP00000321544	FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).	Kelch repeat and BTB domain containing 11.	0.492
KBTBD11	ERICH1	ENSP00000321544	ENSP00000262109	Kelch repeat and BTB domain containing 11.	Glutamate-rich protein 1; Glutamate rich 1.	0.434
KBTBD11	FGD2	ENSP00000321544	ENSP00000274963	Kelch repeat and BTB domain containing 11.	FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).	0.492
KBTBD11	TDRP	ENSP00000321544	ENSP00000430325	Kelch repeat and BTB domain containing 11.	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.401
KBTBD11	ZNF596	ENSP00000321544	ENSP00000381613	Kelch repeat and BTB domain containing 11.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.474
TDRP	ERICH1	ENSP00000430325	ENSP00000262109	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	Glutamate-rich protein 1; Glutamate rich 1.	0.561
TDRP	FBXO25	ENSP00000430325	ENSP00000372274	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	0.706
TDRP	KBTBD11	ENSP00000430325	ENSP00000321544	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	Kelch repeat and BTB domain containing 11.	0.401
TDRP	ZNF596	ENSP00000430325	ENSP00000381613	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.658
ZNF596	ERICH1	ENSP00000381613	ENSP00000262109	Zinc finger protein 596; May be involved in transcriptional regulation.	Glutamate-rich protein 1; Glutamate rich 1.	0.605
ZNF596	FBXO25	ENSP00000381613	ENSP00000372274	Zinc finger protein 596; May be involved in transcriptional regulation.	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	0.607
ZNF596	KBTBD11	ENSP00000381613	ENSP00000321544	Zinc finger protein 596; May be involved in transcriptional regulation.	Kelch repeat and BTB domain containing 11.	0.474
ZNF596	TDRP	ENSP00000381613	ENSP00000430325	Zinc finger protein 596; May be involved in transcriptional regulation.	Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.	0.658