(5 nodes) Mixed, incl. Transmembrane protein TMEM114/TMEM235, and Trochlear nerve disease network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OR6K6	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
	KRTAP12-3	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family. (96 aa)
	TMEM235	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family. (223 aa)
	OR10Z1	Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
	OR4E2	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRTAP12-3	OR10Z1	ENSP00000381005	ENSP00000493003	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.652
KRTAP12-3	OR4E2	ENSP00000381005	ENSP00000493386	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.659
KRTAP12-3	OR6K6	ENSP00000381005	ENSP00000357126	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.628
KRTAP12-3	TMEM235	ENSP00000381005	ENSP00000402790	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.542
OR10Z1	KRTAP12-3	ENSP00000493003	ENSP00000381005	Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.652
OR10Z1	TMEM235	ENSP00000493003	ENSP00000402790	Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.582
OR4E2	KRTAP12-3	ENSP00000493386	ENSP00000381005	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.659
OR4E2	OR6K6	ENSP00000493386	ENSP00000357126	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.568
OR4E2	TMEM235	ENSP00000493386	ENSP00000402790	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.590
OR6K6	KRTAP12-3	ENSP00000357126	ENSP00000381005	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.628
OR6K6	OR4E2	ENSP00000357126	ENSP00000493386	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.568
OR6K6	TMEM235	ENSP00000357126	ENSP00000402790	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	0.543
TMEM235	KRTAP12-3	ENSP00000402790	ENSP00000381005	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.542
TMEM235	OR10Z1	ENSP00000402790	ENSP00000493003	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.582
TMEM235	OR4E2	ENSP00000402790	ENSP00000493386	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.590
TMEM235	OR6K6	ENSP00000402790	ENSP00000357126	Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.543