STRINGSTRING
TMPRSS5 TMPRSS5 TMEM268 TMEM268 OR2B3 OR2B3 TMEM266 TMEM266 SSC5D SSC5D TMEM196 TMEM196 CCDC198 CCDC198 CDC42SE2 CDC42SE2 SLC35F4 SLC35F4 OR10G6 OR10G6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMPRSS5Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family. (457 aa)
TMEM268Transmembrane protein 268. (343 aa)
OR2B3Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
TMEM266Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. (531 aa)
SSC5DSoluble scavenger receptor cysteine-rich domain-containing protein SSC5D; Binds to extracellular matrix proteins. Binds to pathogen- associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). (1573 aa)
TMEM196Transmembrane protein 196. (179 aa)
CCDC198Uncharacterized protein CCDC198; Coiled-coil domain containing 198. (336 aa)
CDC42SE2CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family. (84 aa)
SLC35F4Solute carrier family 35 member F4; Putative solute transporter. (485 aa)
OR10G6Olfactory receptor 10G6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (332 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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