(5 nodes) Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway, and Tetratricopeptide repeat network (Homo sapiens)

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Your Input:
	APPBP2	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. (585 aa)
	FEM1C	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. (617 aa)
	KLHDC2	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. (406 aa)
	KLHDC3	Kelch domain-containing protein 3; May be involved in meiotic recombination process. (382 aa)
	PRAMEF6	PRAME family member 6; Belongs to the PRAME family. (476 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPBP2	FEM1C	ENSP00000083182	ENSP00000274457	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.944
APPBP2	KLHDC2	ENSP00000083182	ENSP00000298307	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	0.948
APPBP2	KLHDC3	ENSP00000083182	ENSP00000313995	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.949
APPBP2	PRAMEF6	ENSP00000083182	ENSP00000365360	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	PRAME family member 6; Belongs to the PRAME family.	0.937
FEM1C	APPBP2	ENSP00000274457	ENSP00000083182	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	0.944
FEM1C	KLHDC2	ENSP00000274457	ENSP00000298307	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	0.943
FEM1C	KLHDC3	ENSP00000274457	ENSP00000313995	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.941
FEM1C	PRAMEF6	ENSP00000274457	ENSP00000365360	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	PRAME family member 6; Belongs to the PRAME family.	0.938
KLHDC2	APPBP2	ENSP00000298307	ENSP00000083182	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	0.948
KLHDC2	FEM1C	ENSP00000298307	ENSP00000274457	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.943
KLHDC2	KLHDC3	ENSP00000298307	ENSP00000313995	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.932
KLHDC2	PRAMEF6	ENSP00000298307	ENSP00000365360	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	PRAME family member 6; Belongs to the PRAME family.	0.940
KLHDC3	APPBP2	ENSP00000313995	ENSP00000083182	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	0.949
KLHDC3	FEM1C	ENSP00000313995	ENSP00000274457	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.941
KLHDC3	KLHDC2	ENSP00000313995	ENSP00000298307	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	0.932
KLHDC3	PRAMEF6	ENSP00000313995	ENSP00000365360	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	PRAME family member 6; Belongs to the PRAME family.	0.942
PRAMEF6	APPBP2	ENSP00000365360	ENSP00000083182	PRAME family member 6; Belongs to the PRAME family.	Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	0.937
PRAMEF6	FEM1C	ENSP00000365360	ENSP00000274457	PRAME family member 6; Belongs to the PRAME family.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.938
PRAMEF6	KLHDC2	ENSP00000365360	ENSP00000298307	PRAME family member 6; Belongs to the PRAME family.	Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	0.940
PRAMEF6	KLHDC3	ENSP00000365360	ENSP00000313995	PRAME family member 6; Belongs to the PRAME family.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.942