(30 nodes) Organellar large ribosomal subunit network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MRPL32	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (188 aa)
	MRPL27	Mitochondrial ribosomal protein L27. (148 aa)
	MRPS7	Mitochondrial ribosomal protein S7. (242 aa)
	MRPL34	Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (92 aa)
	MRPL44	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. (332 aa)
	MRPL3	Mitochondrial ribosomal protein L3. (348 aa)
	MRPL17	Mitochondrial ribosomal protein L17. (175 aa)
	MRPL10	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family. (271 aa)
	MRPL33	Mitochondrial ribosomal protein L33. (65 aa)
	MRPL16	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family. (251 aa)
	MRPL13	Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (178 aa)
	MRPL11	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family. (192 aa)
	MRPL46	Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. (279 aa)
	MRPL1	Mitochondrial ribosomal protein L1. (325 aa)
	MRPS11	Mitochondrial ribosomal protein S11. (194 aa)
	MRPL40	Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. (206 aa)
	MRPL43	Mitochondrial ribosomal protein L43. (235 aa)
	MRPL24	Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family. (216 aa)
	MRPL21	Mitochondrial ribosomal protein L21. (205 aa)
	MRPL9	Mitochondrial ribosomal protein L9. (267 aa)
	MRPL41	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. (137 aa)
	MRPS16	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (137 aa)
	MRPS15	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family. (257 aa)
	MRPL2	Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. (305 aa)
	MRPL19	Mitochondrial ribosomal protein L19. (292 aa)
	MRPL23	Mitochondrial ribosomal protein L23. (153 aa)
	MRPS6	Mitochondrial ribosomal protein S6. (125 aa)
	MRPS12	Mitochondrial ribosomal protein S12. (138 aa)
	MRPL47	Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family. (250 aa)
	MRPL22	Mitochondrial ribosomal protein L22. (206 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MRPL1	MRPL10	ENSP00000315017	ENSP00000290208	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	0.980
MRPL1	MRPL11	ENSP00000315017	ENSP00000308897	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.	0.998
MRPL1	MRPL13	ENSP00000315017	ENSP00000306548	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.	0.994
MRPL1	MRPL16	ENSP00000315017	ENSP00000300151	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	0.979
MRPL1	MRPL17	ENSP00000315017	ENSP00000288937	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L17.	0.996
MRPL1	MRPL19	ENSP00000315017	ENSP00000377486	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L19.	0.998
MRPL1	MRPL2	ENSP00000315017	ENSP00000373404	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family.	0.992
MRPL1	MRPL21	ENSP00000315017	ENSP00000354580	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L21.	0.997
MRPL1	MRPL22	ENSP00000315017	ENSP00000431040	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L22.	0.975
MRPL1	MRPL23	ENSP00000315017	ENSP00000380466	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L23.	0.933
MRPL1	MRPL24	ENSP00000315017	ENSP00000354525	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family.	0.982
MRPL1	MRPL27	ENSP00000315017	ENSP00000225969	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L27.	0.996
MRPL1	MRPL3	ENSP00000315017	ENSP00000264995	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L3.	0.993
MRPL1	MRPL32	ENSP00000315017	ENSP00000223324	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.997
MRPL1	MRPL33	ENSP00000315017	ENSP00000296102	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L33.	0.994
MRPL1	MRPL34	ENSP00000315017	ENSP00000252602	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family.	0.895
MRPL1	MRPL40	ENSP00000315017	ENSP00000333401	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family.	0.952
MRPL1	MRPL41	ENSP00000315017	ENSP00000360498	Mitochondrial ribosomal protein L1.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.943
MRPL1	MRPL43	ENSP00000315017	ENSP00000339844	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L43.	0.928
MRPL1	MRPL44	ENSP00000315017	ENSP00000258383	Mitochondrial ribosomal protein L1.	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.	0.932