(5 nodes) SAGA complex network (Homo sapiens)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	SUPT7L	SPT7 like, STAGA complex subunit gamma. (414 aa)
	TRRAP	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...] (3859 aa)
	TADA1	Transcriptional adapter 1; Probably involved in transcriptional regulation. (335 aa)
	SUPT3H	Transcription initiation protein SPT3 homolog; Probable transcriptional activator. (328 aa)
	SUPT20H	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family. (811 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SUPT20H	SUPT3H	ENSP00000417510	ENSP00000360515	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	0.999
SUPT20H	SUPT7L	ENSP00000417510	ENSP00000336750	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	SPT7 like, STAGA complex subunit gamma.	0.999
SUPT20H	TADA1	ENSP00000417510	ENSP00000356848	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	Transcriptional adapter 1; Probably involved in transcriptional regulation.	0.999
SUPT20H	TRRAP	ENSP00000417510	ENSP00000352925	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	0.999
SUPT3H	SUPT20H	ENSP00000360515	ENSP00000417510	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	0.999
SUPT3H	SUPT7L	ENSP00000360515	ENSP00000336750	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	SPT7 like, STAGA complex subunit gamma.	0.999
SUPT3H	TADA1	ENSP00000360515	ENSP00000356848	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	Transcriptional adapter 1; Probably involved in transcriptional regulation.	0.999
SUPT3H	TRRAP	ENSP00000360515	ENSP00000352925	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	0.999
SUPT7L	SUPT20H	ENSP00000336750	ENSP00000417510	SPT7 like, STAGA complex subunit gamma.	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	0.999
SUPT7L	SUPT3H	ENSP00000336750	ENSP00000360515	SPT7 like, STAGA complex subunit gamma.	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	0.999
SUPT7L	TADA1	ENSP00000336750	ENSP00000356848	SPT7 like, STAGA complex subunit gamma.	Transcriptional adapter 1; Probably involved in transcriptional regulation.	0.999
SUPT7L	TRRAP	ENSP00000336750	ENSP00000352925	SPT7 like, STAGA complex subunit gamma.	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	0.999
TADA1	SUPT20H	ENSP00000356848	ENSP00000417510	Transcriptional adapter 1; Probably involved in transcriptional regulation.	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	0.999
TADA1	SUPT3H	ENSP00000356848	ENSP00000360515	Transcriptional adapter 1; Probably involved in transcriptional regulation.	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	0.999
TADA1	SUPT7L	ENSP00000356848	ENSP00000336750	Transcriptional adapter 1; Probably involved in transcriptional regulation.	SPT7 like, STAGA complex subunit gamma.	0.999
TADA1	TRRAP	ENSP00000356848	ENSP00000352925	Transcriptional adapter 1; Probably involved in transcriptional regulation.	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	0.999
TRRAP	SUPT20H	ENSP00000352925	ENSP00000417510	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.	0.999
TRRAP	SUPT3H	ENSP00000352925	ENSP00000360515	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	0.999
TRRAP	SUPT7L	ENSP00000352925	ENSP00000336750	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	SPT7 like, STAGA complex subunit gamma.	0.999
TRRAP	TADA1	ENSP00000352925	ENSP00000356848	Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...]	Transcriptional adapter 1; Probably involved in transcriptional regulation.	0.999