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RALGAPA2 RALGAPA2 ZNF500 ZNF500 RALGPS1 RALGPS1 RALGAPB RALGAPB GFOD2 GFOD2 JAZF1 JAZF1 NKIRAS2 NKIRAS2 NR2C1 NR2C1 EZHIP EZHIP ZC3H7B ZC3H7B DUSP19 DUSP19 NUTM2G NUTM2G FOXJ3 FOXJ3 GARNL3 GARNL3 CCNB3 CCNB3 GFOD1 GFOD1 MAP7D2 MAP7D2 NUTM2A NUTM2A ZNF816-ZNF321P ZNF816-ZNF321P ZC3H7A ZC3H7A NUTM2B NUTM2B NR2C2AP NR2C2AP NUTM2E NUTM2E NUGGC NUGGC FKBP9 FKBP9 ADIG ADIG EML5 EML5 NR2C2 NR2C2 RALGAPA1 RALGAPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RALGAPA2Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. (1873 aa)
ZNF500Zinc finger protein 500; May be involved in transcriptional regulation. (480 aa)
RALGPS1Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. (557 aa)
RALGAPBRal GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. (1494 aa)
GFOD2Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. (385 aa)
JAZF1Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] (243 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. (191 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] (603 aa)
EZHIPEZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity. (503 aa)
ZC3H7BZinc finger CCCH domain-containing protein 7B; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. (977 aa)
DUSP19Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins. (217 aa)
NUTM2GNUT family member 2G. (741 aa)
FOXJ3Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration. (622 aa)
GARNL3GTPase-activating Rap/Ran-GAP domain-like protein 3; GTPase activating Rap/RanGAP domain like 3. (1013 aa)
CCNB3G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. (1395 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. (390 aa)
MAP7D2MAP7 domain containing 2. (773 aa)
NUTM2ANUT family member 2A. (878 aa)
ZNF816-ZNF321PZNF816-ZNF321P readthrough. (233 aa)
ZC3H7AZinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'- ATA(A/T)-5' motif in the apical loop. (971 aa)
NUTM2BNUT family member 2B. (878 aa)
NR2C2APNuclear receptor 2C2-associated protein; May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes; Belongs to the NR2C2AP family. (167 aa)
NUTM2ENUT family member 2E; Belongs to the NUT family. (878 aa)
NUGGCNuclear GTPase SLIP-GC; Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). (796 aa)
FKBP9Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis. (623 aa)
ADIGAdipogenin; Plays a role in stimulating adipocyte differentiation and development; Belongs to the adipogenin family. (80 aa)
EML5Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (1977 aa)
NR2C2Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response element [...] (615 aa)
RALGAPA1Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. (2495 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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