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ZFY ZFY VCY1B VCY1B VCY VCY TMSB4Y TMSB4Y PRY PRY CDY1 CDY1 CDY1B CDY1B PRY2 PRY2 HSFY1 HSFY1 KDM5D KDM5D BPY2 BPY2 USP9Y USP9Y DDX3Y DDX3Y EIF1AY EIF1AY PCDH11Y PCDH11Y ZFX ZFX BPY2C BPY2C DAZ3 DAZ3 BPY2B BPY2B DAZ2 DAZ2 AMELY AMELY SRY SRY DAZ1 DAZ1 CDY2A CDY2A TSPY1 TSPY1 CDY2B CDY2B UTY UTY PRKY PRKY PRYP3 PRYP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFYZinc finger Y-chromosomal protein; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'. (801 aa)
VCY1BTestis-specific basic protein Y 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family. (125 aa)
VCYVariable charge Y-linked. (125 aa)
TMSB4YThymosin beta-4, Y-chromosomal; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. (44 aa)
PRYPTPN13-like protein, Y-linked; PTPN13 like Y-linked. (147 aa)
CDY1Testis-specific chromodomain protein Y 1; Has histone acetyltransferase activity, with a preference for histone H4. (554 aa)
CDY1BChromodomain Y-linked 1B. (554 aa)
PRY2PTPN13 like Y-linked 2. (147 aa)
HSFY1Heat shock transcription factor Y-linked 1; Belongs to the HSF family. (401 aa)
KDM5DLysine-specific demethylase 5D; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity [...] (1539 aa)
BPY2Basic charge Y-linked 2. (106 aa)
USP9YProbable ubiquitin carboxyl-terminal hydrolase FAF-Y; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable co [...] (2555 aa)
DDX3YATP-dependent RNA helicase DDX3Y; Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (660 aa)
EIF1AYEukaryotic translation initiation factor 1A, Y-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). (144 aa)
PCDH11YProtocadherin 11 Y-linked. (1048 aa)
ZFXZinc finger X-chromosomal protein; Probable transcriptional activator. (844 aa)
BPY2CBasic charge Y-linked 2C. (106 aa)
DAZ3Deleted in azoospermia protein 2; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. (438 aa)
BPY2BBasic charge Y-linked 2B. (106 aa)
DAZ2Deleted in azoospermia 2. (558 aa)
AMELYAmelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (206 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partia [...] (204 aa)
DAZ1Deleted in azoospermia protein 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. (744 aa)
CDY2ATestis-specific chromodomain protein Y 2; May have histone acetyltransferase activity. (555 aa)
TSPY1Testis-specific Y-encoded protein 1; May be involved in sperm differentiation and proliferation. (308 aa)
CDY2BChromodomain Y-linked 2B. (555 aa)
UTYHistone demethylase UTY; Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. Belongs to the UTX family. (1444 aa)
PRKYPutative serine/threonine-protein kinase PRKY; Protein kinase Y-linked; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (277 aa)
PRYP3PTPN13 like Y-linked pseudogene 3. (147 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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