STRINGSTRING
CTTNBP2 CTTNBP2 FGFR1OP2 FGFR1OP2 PLBD1 PLBD1 STRIP2 STRIP2 STRN STRN CTTNBP2NL CTTNBP2NL MAP4K2 MAP4K2 MOB4 MOB4 STK25 STK25 STRN3 STRN3 TRAF3IP3 TRAF3IP3 SIKE1 SIKE1 STRIP1 STRIP1 STK24 STK24 STRN4 STRN4 PDCD10 PDCD10 STK26 STK26 HSPE1-MOB4 HSPE1-MOB4 SLMAP SLMAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTTNBP2Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. (1663 aa)
FGFR1OP2FGFR1 oncogene partner 2; May be involved in wound healing pathway; Belongs to the SIKE family. (253 aa)
PLBD1Phospholipase B-like 1 chain A; In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. (553 aa)
STRIP2Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the STRIP family. (834 aa)
STRNStriatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family. (780 aa)
CTTNBP2NLCTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like. (639 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6- dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides [...] (820 aa)
MOB4MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. (225 aa)
STK25Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (426 aa)
STRN3Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. (797 aa)
TRAF3IP3TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation. (551 aa)
SIKE1Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways; Belongs to the SIKE family. (211 aa)
STRIP1Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. (837 aa)
STK24Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] (443 aa)
STRN4Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. (760 aa)
PDCD10Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. (212 aa)
STK26Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. (416 aa)
HSPE1-MOB4HSPE1-MOB4 readthrough; Belongs to the GroES chaperonin family. (261 aa)
SLMAPSarcolemmal membrane-associated protein; May play a role during myoblast fusion; Belongs to the SLMAP family. (828 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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