STRINGSTRING
LDHD LDHD LDHAL6B LDHAL6B PKM PKM ME2 ME2 PKLR PKLR ME1 ME1 LDHC LDHC ME3 ME3 LDHA LDHA PC PC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDHDProbable D-lactate dehydrogenase, mitochondrial; Involved in D-lactate, but not L-lactate catabolic process. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (507 aa)
LDHAL6BLactate dehydrogenase A like 6B. (381 aa)
PKMPyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] (531 aa)
ME2NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family. (584 aa)
PKLRPyruvate kinase PKLR; Plays a key role in glycolysis. (574 aa)
ME1Malic enzyme 1. (572 aa)
LDHCL-lactate dehydrogenase C chain; Possible role in sperm motility. (332 aa)
ME3NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family. (604 aa)
LDHALactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family. (361 aa)
PCPyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. (1178 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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