node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf45 | NUFIP1 | ENSP00000447057 | ENSP00000368459 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | 0.439 |
C12orf45 | PIH1D1 | ENSP00000447057 | ENSP00000262265 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | 0.436 |
C12orf45 | RUVBL1 | ENSP00000447057 | ENSP00000318297 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.799 |
C12orf45 | RUVBL2 | ENSP00000447057 | ENSP00000473172 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively re [...] | 0.770 |
C12orf45 | SNU13 | ENSP00000447057 | ENSP00000383949 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | 0.498 |
C12orf45 | ZNHIT3 | ENSP00000447057 | ENSP00000484687 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | Zinc finger HIT-type containing 3. | 0.575 |
C12orf45 | ZNHIT6 | ENSP00000447057 | ENSP00000359606 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family. | 0.451 |
NUFIP1 | C12orf45 | ENSP00000368459 | ENSP00000447057 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | 0.439 |
NUFIP1 | PIH1D1 | ENSP00000368459 | ENSP00000262265 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | 0.941 |
NUFIP1 | RUVBL1 | ENSP00000368459 | ENSP00000318297 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.811 |
NUFIP1 | RUVBL2 | ENSP00000368459 | ENSP00000473172 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively re [...] | 0.825 |
NUFIP1 | SNU13 | ENSP00000368459 | ENSP00000383949 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | 0.965 |
NUFIP1 | TAF9 | ENSP00000368459 | ENSP00000370193 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | Transcription initiation factor TFIID subunit 9; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | 0.831 |
NUFIP1 | ZNHIT3 | ENSP00000368459 | ENSP00000484687 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | Zinc finger HIT-type containing 3. | 0.999 |
NUFIP1 | ZNHIT6 | ENSP00000368459 | ENSP00000359606 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family. | 0.982 |
PIH1D1 | C12orf45 | ENSP00000262265 | ENSP00000447057 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45. | 0.436 |
PIH1D1 | NUFIP1 | ENSP00000262265 | ENSP00000368459 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA. | 0.941 |
PIH1D1 | PIH1D2 | ENSP00000262265 | ENSP00000280350 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | PIH1 domain containing 2. | 0.779 |
PIH1D1 | RUVBL1 | ENSP00000262265 | ENSP00000318297 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.999 |
PIH1D1 | RUVBL2 | ENSP00000262265 | ENSP00000473172 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively re [...] | 0.999 |