STRINGSTRING
MRPS14 MRPS14 MRPS18B MRPS18B MRPS9 MRPS9 PTCD3 PTCD3 MRPS25 MRPS25 DHX29 DHX29 HBA2 HBA2 RPS4Y1 RPS4Y1 MRPS7 MRPS7 RPS12 RPS12 MRPS34 MRPS34 MRPS35 MRPS35 MRPS10 MRPS10 MRPS5 MRPS5 MRPS28 MRPS28 RPS3 RPS3 MRPS17 MRPS17 MRPS18C MRPS18C RPS23 RPS23 NPM1 NPM1 MRPS31 MRPS31 MRPS11 MRPS11 MRPS24 MRPS24 RPS15A RPS15A MRPS23 MRPS23 MRPS33 MRPS33 HBA1 HBA1 RACK1 RACK1 MRPS27 MRPS27 RPS20 RPS20 FAU FAU RPS25 RPS25 RPS13 RPS13 MRPL42 MRPL42 MRPS21 MRPS21 RPS15 RPS15 RPS19 RPS19 RPS28 RPS28 RPS5 RPS5 RPS27L RPS27L RPS2 RPS2 AURKAIP1 AURKAIP1 RPS21 RPS21 RPS3A RPS3A RPS26 RPS26 DAP3 DAP3 MRPS2 MRPS2 MRPS18A MRPS18A CHCHD1 CHCHD1 MRPS16 MRPS16 MRPS15 MRPS15 RPS4X RPS4X RPS16 RPS16 MRPS26 MRPS26 RPS6 RPS6 RPS10 RPS10 RPS4Y2 RPS4Y2 RPS7 RPS7 ISG15 ISG15 RPS17 RPS17 RPS27 RPS27 RPS9 RPS9 RPS29 RPS29 RPS8 RPS8 MRPS6 MRPS6 MRPS12 MRPS12 RPS14 RPS14 UBA52 UBA52 RPSA RPSA hCG_1984214 hCG_1984214 B3GALT4 B3GALT4 RPS27A RPS27A RPS11 RPS11 RPS18 RPS18 RPS24 RPS24 EIF2A EIF2A MRPS22 MRPS22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRPS14Mitochondrial ribosomal protein S14. (128 aa)
MRPS18BMitochondrial ribosomal protein S18B; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. (258 aa)
MRPS9Mitochondrial ribosomal protein S9. (396 aa)
PTCD3Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation. (689 aa)
MRPS25Mitochondrial ribosomal protein S25. (173 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Belongs to the DEAD box helicase family. DEAH subfamily. (1369 aa)
HBA2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (142 aa)
RPS4Y1Ribosomal protein S4 Y-linked 1; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
MRPS7Mitochondrial ribosomal protein S7. (242 aa)
RPS12Ribosomal protein S12. (132 aa)
MRPS3428S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Belongs to the mitochondrion-specific ribosomal protein mS34 family. (225 aa)
MRPS35Mitochondrial ribosomal protein S35. (323 aa)
MRPS10Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family. (201 aa)
MRPS5Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. (430 aa)
MRPS28Mitochondrial ribosomal protein S28; Belongs to the bacterial ribosomal protein bS1 family. (187 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa)
MRPS17Mitochondrial ribosomal protein S17; Belongs to the universal ribosomal protein uS17 family. (130 aa)
MRPS18CMitochondrial ribosomal protein S18C. (142 aa)
RPS2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
NPM1Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...] (294 aa)
MRPS31Mitochondrial ribosomal protein S31. (395 aa)
MRPS11Mitochondrial ribosomal protein S11. (194 aa)
MRPS24Mitochondrial ribosomal protein S24; Belongs to the universal ribosomal protein uS3 family. (167 aa)
RPS15A40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis. (130 aa)
MRPS23Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family. (190 aa)
MRPS33Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family. (106 aa)
HBA1Hemoglobin subunit alpha 1. (142 aa)
RACK1Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein [...] (317 aa)
MRPS2728S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth. (428 aa)
RPS20Ribosomal protein S20. (142 aa)
FAUUbiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. (133 aa)
RPS25Ribosomal protein S25. (125 aa)
RPS13Ribosomal protein S13. (151 aa)
MRPL42Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family. (142 aa)
MRPS21Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (87 aa)
RPS15Ribosomal protein S15. (152 aa)
RPS1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
RPS28Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
RPS540S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
RPS27LRibosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
RPS2Ribosomal protein S2. (293 aa)
AURKAIP1Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation. (199 aa)
RPS21Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. (264 aa)
RPS26Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
DAP328S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. (398 aa)
MRPS228S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. (296 aa)
MRPS18AMitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily. (196 aa)
CHCHD1Coiled-coil-helix-coiled-coil-helix domain containing 1. (118 aa)
MRPS16Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (137 aa)
MRPS15Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family. (257 aa)
RPS4XRibosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPS16Ribosomal protein S16. (152 aa)
MRPS26Mitochondrial ribosomal protein S26; Belongs to the mitochondrion-specific ribosomal protein mS26 family. (205 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPS1040S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family. (165 aa)
RPS4Y2Ribosomal protein S4 Y-linked 2; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPS740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
ISG15Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhib [...] (165 aa)
RPS17Ribosomal protein S17. (135 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs ; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
RPS9Ribosomal protein S9. (194 aa)
RPS29Ribosomal protein S29. (67 aa)
RPS8Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
MRPS6Mitochondrial ribosomal protein S6. (125 aa)
MRPS12Mitochondrial ribosomal protein S12. (138 aa)
RPS14Ribosomal protein S14. (151 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] (300 aa)
hCG_1984214HCG1984214, isoform CRA_a. (225 aa)
B3GALT4Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. (378 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
RPS11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
RPS1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
RPS2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. (289 aa)
EIF2AEukaryotic translation initiation factor 2A, N-terminally processed; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family. (585 aa)
MRPS22Mitochondrial ribosomal protein S22. (360 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.