STRINGSTRING
RPS17 RPS17 RPS12 RPS12 RPS4Y1 RPS4Y1 HBA2 HBA2 DHX29 DHX29 RPS11 RPS11 RPS27A RPS27A RPS3 RPS3 RPS23 RPS23 MRPS11 MRPS11 RPS15A RPS15A HBA1 HBA1 RPS27L RPS27L RPS2 RPS2 RPS21 RPS21 RPS3A RPS3A RPS26 RPS26 RPS4X RPS4X RPS16 RPS16 RPS6 RPS6 RPS9 RPS9 RPS29 RPS29 RPS8 RPS8 RPS14 RPS14 UBA52 UBA52 RPSA RPSA B3GALT4 B3GALT4 RPS18 RPS18 RPS24 RPS24 EIF2A EIF2A RACK1 RACK1 RPS20 RPS20 FAU FAU RPS25 RPS25 RPS13 RPS13 RPS15 RPS15 RPS19 RPS19 RPS28 RPS28 RPS5 RPS5 RPS10 RPS10 RPS4Y2 RPS4Y2 RPS7 RPS7 RPS27 RPS27 ISG15 ISG15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS17Ribosomal protein S17. (135 aa)
RPS12Ribosomal protein S12. (132 aa)
RPS4Y1Ribosomal protein S4 Y-linked 1; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
HBA2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (142 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Belongs to the DEAD box helicase family. DEAH subfamily. (1369 aa)
RPS11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa)
RPS2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
MRPS11Mitochondrial ribosomal protein S11. (194 aa)
RPS15A40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis. (130 aa)
HBA1Hemoglobin subunit alpha 1. (142 aa)
RPS27LRibosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
RPS2Ribosomal protein S2. (293 aa)
RPS21Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. (264 aa)
RPS26Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
RPS4XRibosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPS16Ribosomal protein S16. (152 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPS9Ribosomal protein S9. (194 aa)
RPS29Ribosomal protein S29. (67 aa)
RPS8Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
RPS14Ribosomal protein S14. (151 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] (300 aa)
B3GALT4Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. (378 aa)
RPS1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
RPS2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. (289 aa)
EIF2AEukaryotic translation initiation factor 2A, N-terminally processed; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family. (585 aa)
RACK1Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein [...] (317 aa)
RPS20Ribosomal protein S20. (142 aa)
FAUUbiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. (133 aa)
RPS25Ribosomal protein S25. (125 aa)
RPS13Ribosomal protein S13. (151 aa)
RPS15Ribosomal protein S15. (152 aa)
RPS1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
RPS28Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
RPS540S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
RPS1040S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family. (165 aa)
RPS4Y2Ribosomal protein S4 Y-linked 2; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPS740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs ; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
ISG15Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhib [...] (165 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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