(15 nodes) Extracellular matrix structural constituent conferring compression resistance network (Homo sapiens)

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Your Input:
	HSPG2	Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require [...] (4391 aa)
	ENAM	Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. (1142 aa)
	AMELY	Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (206 aa)
	AMELX	Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (205 aa)
	TUFT1	Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family. (390 aa)
	PRELP	Prolargin; May anchor basement membranes to the underlying connective tissue. (382 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. (368 aa)
	AMBN	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. (447 aa)
	PRG2	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. (222 aa)
	PRG3	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. (225 aa)
	LUM	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (338 aa)
	VCAN	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3396 aa)
	STATH	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface. (62 aa)
	CHADL	Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. (762 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELX	ENSP00000313809	ENSP00000370088	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.984
AMBN	AMELY	ENSP00000313809	ENSP00000372505	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.688
AMBN	BGN	ENSP00000313809	ENSP00000327336	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Biglycan; May be involved in collagen fiber assembly.	0.456
AMBN	ENAM	ENSP00000313809	ENSP00000379383	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.999
AMBN	TUFT1	ENSP00000313809	ENSP00000357842	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family.	0.992
AMELX	AMBN	ENSP00000370088	ENSP00000313809	Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.984
AMELX	ENAM	ENSP00000370088	ENSP00000379383	Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.984
AMELX	TUFT1	ENSP00000370088	ENSP00000357842	Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family.	0.908
AMELY	AMBN	ENSP00000372505	ENSP00000313809	Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.688
AMELY	ENAM	ENSP00000372505	ENSP00000379383	Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.799
BGN	AMBN	ENSP00000327336	ENSP00000313809	Biglycan; May be involved in collagen fiber assembly.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.456
BGN	DCN	ENSP00000327336	ENSP00000052754	Biglycan; May be involved in collagen fiber assembly.	Decorin; May affect the rate of fibrils formation.	0.989
BGN	HSPG2	ENSP00000327336	ENSP00000363827	Biglycan; May be involved in collagen fiber assembly.	Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require [...]	0.997
BGN	LUM	ENSP00000327336	ENSP00000266718	Biglycan; May be involved in collagen fiber assembly.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.918
BGN	PRELP	ENSP00000327336	ENSP00000343924	Biglycan; May be involved in collagen fiber assembly.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.681
BGN	VCAN	ENSP00000327336	ENSP00000265077	Biglycan; May be involved in collagen fiber assembly.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.951
CHADL	DCN	ENSP00000216241	ENSP00000052754	Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.	Decorin; May affect the rate of fibrils formation.	0.413
DCN	BGN	ENSP00000052754	ENSP00000327336	Decorin; May affect the rate of fibrils formation.	Biglycan; May be involved in collagen fiber assembly.	0.989
DCN	CHADL	ENSP00000052754	ENSP00000216241	Decorin; May affect the rate of fibrils formation.	Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.	0.413
DCN	HSPG2	ENSP00000052754	ENSP00000363827	Decorin; May affect the rate of fibrils formation.	Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require [...]	0.986