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PI3 PI3 KRT5 KRT5 KRT1 KRT1 KRT75 KRT75 KRT6C KRT6C KRT6B KRT6B KRT85 KRT85 KRT84 KRT84 KRT82 KRT82 PKP1 PKP1 KRT71 KRT71 KRT10 KRT10 KRT83 KRT83 KRT72 KRT72 KRT78 KRT78 KRT73 KRT73 KRT74 KRT74 KRT2 KRT2 KRT79 KRT79 KRT36 KRT36 KRT7 KRT7 KRT76 KRT76 KRT77 KRT77 KRTAP1-3 KRTAP1-3 LOR LOR SPRR2E SPRR2E SPRR1A SPRR1A FLG FLG KRT6A KRT6A KRT81 KRT81 PNPLA1 PNPLA1 KRT80 KRT80 KRT3 KRT3 KRTAP5-8 KRTAP5-8 KRT86 KRT86 KRT4 KRT4 KRT8 KRT8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PI3Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1). (117 aa)
KRT5Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family. (590 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. (644 aa)
KRT75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. (551 aa)
KRT6CKeratin, type II cytoskeletal 6C; Keratin 6C; Belongs to the intermediate filament family. (564 aa)
KRT6BKeratin, type II cytoskeletal 6B; Keratin 6B; Belongs to the intermediate filament family. (564 aa)
KRT85Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family. (507 aa)
KRT84Keratin, type II cuticular Hb4; Keratin 84. (600 aa)
KRT82Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family. (513 aa)
PKP1Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. (747 aa)
KRT71Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. (523 aa)
KRT10Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. (584 aa)
KRT83Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family. (493 aa)
KRT72Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). (511 aa)
KRT78Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. (520 aa)
KRT73Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). (540 aa)
KRT74Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). (529 aa)
KRT2Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). (639 aa)
KRT79Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family. (535 aa)
KRT36Keratin, type I cuticular Ha6; Keratin 36; Belongs to the intermediate filament family. (467 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Belongs to the intermediate filament family. (469 aa)
KRT76Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family. (638 aa)
KRT77Keratin, type II cytoskeletal 1b; Keratin 77. (578 aa)
KRTAP1-3Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. (167 aa)
LORLoricrin; Major keratinocyte cell envelope protein. (312 aa)
SPRR2ESmall proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. (72 aa)
SPRR1ACornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. (89 aa)
FLGFilaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. (4061 aa)
KRT6AKeratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. (564 aa)
KRT81Keratin, type II cuticular Hb1; Keratin 81. (505 aa)
PNPLA1Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism. (532 aa)
KRT80Keratin, type II cytoskeletal 80; Keratin 80. (452 aa)
KRT3Keratin, type II cytoskeletal 3; Keratin 3; Belongs to the intermediate filament family. (628 aa)
KRTAP5-8Keratin-associated protein 5-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family. (187 aa)
KRT86Keratin, type II cuticular Hb6. (486 aa)
KRT4Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. (520 aa)
KRT8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family. (511 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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