(4 nodes) Positive regulation of prostaglandin-endoperoxide synthase activity network (Homo sapiens)

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Your Input:
	EDN2	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. (178 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
	EDN3	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. (238 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. (212 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDN2	ENSP00000368683	ENSP00000361668	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides.	0.950
EDN1	EDN3	ENSP00000368683	ENSP00000337128	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.971
EDN2	EDN1	ENSP00000361668	ENSP00000368683	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family.	0.950
EDN2	EDN3	ENSP00000361668	ENSP00000337128	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.927
EDN3	EDN1	ENSP00000337128	ENSP00000368683	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family.	0.971
EDN3	EDN2	ENSP00000337128	ENSP00000361668	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides.	0.927