STRINGSTRING
GCG GCG MTRNR2L1 MTRNR2L1 MTRNR2L8 MTRNR2L8 MTRNR2L12 MTRNR2L12 MTRNR2L3 MTRNR2L3 MTRNR2L10 MTRNR2L10 MTRNR2L7 MTRNR2L7 FZD3 FZD3 PAK2 PAK2 CIDEA CIDEA RFFL RFFL CXCR3 CXCR3 BCL2L1 BCL2L1 DFFA DFFA RNF34 RNF34 MTRNR2L11 MTRNR2L11 MTRNR2L13 MTRNR2L13 MTRNR2L6 MTRNR2L6 MTRNR2L4 MTRNR2L4 MTRNR2L5 MTRNR2L5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, fro [...] (180 aa)
MTRNR2L1Humanin-like 1; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L8Humanin-like 8; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L12MT-RNR2 like 12. (24 aa)
MTRNR2L3Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L10Humanin-like 10; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L7Humanin-like 7; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
FZD3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa)
PAK2Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa)
CIDEACell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid tran [...] (219 aa)
RFFLE3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor ne [...] (363 aa)
CXCR3C-X-C chemokine receptor type 3; [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G- protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. [Isoform 3]: Mediates the activity of CXCL11. (415 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. (233 aa)
DFFADNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). (331 aa)
RNF34E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (373 aa)
MTRNR2L11Humanin-like 11; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L13Humanin-like 13; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L6Humanin-like 6; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
MTRNR2L4Humanin-like 4; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (28 aa)
MTRNR2L5Humanin-like 5; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. (24 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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