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MRPL4 MRPL4 RPL18A RPL18A MRPL32 MRPL32 MRPL2 MRPL2 MRPL50 MRPL50 RPL10A RPL10A MRPS18A MRPS18A MRPL14 MRPL14 MRPL41 MRPL41 RPL5 RPL5 RPL19 RPL19 MRPL27 MRPL27 MRPL51 MRPL51 FXR2 FXR2 MRPL34 MRPL34 MRPL53 MRPL53 MRPL44 MRPL44 RPL35 RPL35 MRPL15 MRPL15 RPL6 RPL6 RPL23A RPL23A UBA52 UBA52 RPL8 RPL8 RPL31 RPL31 MRPL23 MRPL23 RPL24 RPL24 MRPL19 MRPL19 RPL13A RPL13A MRPL3 MRPL3 RPL3L RPL3L MRPL49 MRPL49 MRPL22 MRPL22 RPLP2 RPLP2 RPL18 RPL18 RPL41 RPL41 RPLP0 RPLP0 MRPL42 MRPL42 RPL26 RPL26 RPL36 RPL36 MPV17L2 MPV17L2 MRPL37 MRPL37 MTERF4 MTERF4 MRPL45 MRPL45 RPL35A RPL35A RPL11 RPL11 MRPL28 MRPL28 BIN2 BIN2 MRPL17 MRPL17 MRPL10 MRPL10 RPL29 RPL29 MRPL33 MRPL33 MRPL13 MRPL13 MRPL39 MRPL39 MRPL58 MRPL58 MRPL16 MRPL16 RPL10L RPL10L MRPL35 MRPL35 MRPL30 MRPL30 RPL30 RPL30 MRPL12 MRPL12 RPL7 RPL7 MRPS30 MRPS30 MRPL36 MRPL36 NSUN4 NSUN4 MRPL47 MRPL47 RPL32 RPL32 RPL10 RPL10 RPL36A RPL36A MRPL55 MRPL55 MRPL40 MRPL40 MRPL54 MRPL54 MRPL46 MRPL46 RPL4 RPL4 MRPL57 MRPL57 RPL38 RPL38 RPL15 RPL15 MRPL11 MRPL11 MRPL48 MRPL48 MRPL9 MRPL9 MRPL18 MRPL18 RPL39 RPL39 RPL12 RPL12 MRPL21 MRPL21 MRPL24 MRPL24 MRPL52 MRPL52 RPL22 RPL22 RPLP1 RPLP1 RPL36AL RPL36AL MRPL38 MRPL38 RPL3 RPL3 MRPL20 MRPL20 MRPL43 MRPL43
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRPL4Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (311 aa)
RPL18ARibosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. (176 aa)
MRPL32Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (188 aa)
MRPL2Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. (305 aa)
MRPL50Mitochondrial ribosomal protein L50. (158 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. (217 aa)
MRPS18AMitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily. (196 aa)
MRPL1439S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). (145 aa)
MRPL4139S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. (137 aa)
RPL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
MRPL27Mitochondrial ribosomal protein L27. (148 aa)
MRPL51Mitochondrial ribosomal protein L51; Belongs to the mitochondrion-specific ribosomal protein mL51 family. (128 aa)
FXR2Fragile X mental retardation syndrome-related protein 2; RNA-binding protein; Belongs to the FMR1 family. (673 aa)
MRPL34Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (92 aa)
MRPL53Mitochondrial ribosomal protein L53. (112 aa)
MRPL4439S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. (332 aa)
RPL3560S ribosomal protein L35; Component of the large ribosomal subunit. (123 aa)
MRPL15Mitochondrial ribosomal protein L15. (296 aa)
RPL660S ribosomal protein L6; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL6 family. (288 aa)
RPL23A60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. (156 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit. (257 aa)
RPL31Ribosomal protein L31. (128 aa)
MRPL23Mitochondrial ribosomal protein L23. (153 aa)
RPL24Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
MRPL19Mitochondrial ribosomal protein L19. (292 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppre [...] (203 aa)
MRPL3Mitochondrial ribosomal protein L3. (348 aa)
RPL3LRibosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family. (407 aa)
MRPL49Mitochondrial ribosomal protein L49. (166 aa)
MRPL22Mitochondrial ribosomal protein L22. (206 aa)
RPLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis. (115 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
RPL41Ribosomal protein L41. (25 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
MRPL42Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family. (142 aa)
RPL2660S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
RPL3660S ribosomal protein L36; Component of the large ribosomal subunit. (105 aa)
MPV17L2Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis ; Belongs to the peroxisomal membrane protein PXMP2/4 family. (206 aa)
MRPL37Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family. (483 aa)
MTERF4Transcription termination factor 4, mitochondrial; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S); Belongs to the mTERF family. (381 aa)
MRPL45Mitochondrial ribosomal protein L45. (306 aa)
RPL35A60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa)
MRPL28Mitochondrial ribosomal protein L28. (256 aa)
BIN2Bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. (597 aa)
MRPL17Mitochondrial ribosomal protein L17. (175 aa)
MRPL10Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family. (271 aa)
RPL2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (159 aa)
MRPL33Mitochondrial ribosomal protein L33. (65 aa)
MRPL13Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (178 aa)
MRPL39Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family. (353 aa)
MRPL58Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. (206 aa)
MRPL16Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family. (251 aa)
RPL10L60S ribosomal protein L10-like; May play a role in compensating for the inactivated X-linked gene during spermatogenesis. (214 aa)
MRPL35Mitochondrial ribosomal protein L35. (188 aa)
MRPL30Mitochondrial ribosomal protein L30. (161 aa)
RPL30Ribosomal protein L30. (115 aa)
MRPL1239S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family. (198 aa)
RPL760S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs. (248 aa)
MRPS30Mitochondrial ribosomal protein S30. (439 aa)
MRPL36Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (103 aa)
NSUN45-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4; B [...] (384 aa)
MRPL47Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family. (250 aa)
RPL32Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
RPL1060S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. (214 aa)
RPL36ARibosomal protein L36a. (142 aa)
MRPL55Mitochondrial ribosomal protein L55. (164 aa)
MRPL40Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family. (206 aa)
MRPL54Mitochondrial ribosomal protein L54. (138 aa)
MRPL46Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. (279 aa)
RPL4Ribosomal protein L4. (427 aa)
MRPL57Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family. (102 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
RPL15Ribosomal protein L15. (204 aa)
MRPL11Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family. (192 aa)
MRPL48Mitochondrial ribosomal protein L48. (212 aa)
MRPL9Mitochondrial ribosomal protein L9. (267 aa)
MRPL1839S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. (180 aa)
RPL39Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RPL1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
MRPL21Mitochondrial ribosomal protein L21. (205 aa)
MRPL24Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family. (216 aa)
MRPL52Mitochondrial ribosomal protein L52. (123 aa)
RPL22Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family. (128 aa)
RPLP160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
RPL36ALRibosomal protein L36a like; Belongs to the eukaryotic ribosomal protein eL42 family. (106 aa)
MRPL38Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily. (380 aa)
RPL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
MRPL20Mitochondrial ribosomal protein L20. (149 aa)
MRPL43Mitochondrial ribosomal protein L43. (235 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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