(6 nodes) Alveolar lamellar body network (Homo sapiens)

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Your Input:
	CTSH	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa)
	NAPSA	Napsin-A; May be involved in processing of pneumocyte surfactant precursors. (420 aa)
	LAMP3	Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity. (416 aa)
	ABCA3	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family. (1704 aa)
	SFTPC	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. (197 aa)
	SFTPB	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. (393 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA3	LAMP3	ENSP00000301732	ENSP00000265598	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity.	0.450
ABCA3	SFTPB	ENSP00000301732	ENSP00000499683	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	0.960
ABCA3	SFTPC	ENSP00000301732	ENSP00000316152	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	0.899
CTSH	NAPSA	ENSP00000220166	ENSP00000253719	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.672
CTSH	SFTPB	ENSP00000220166	ENSP00000499683	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	0.715
CTSH	SFTPC	ENSP00000220166	ENSP00000316152	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	0.581
LAMP3	ABCA3	ENSP00000265598	ENSP00000301732	Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity.	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	0.450
LAMP3	SFTPB	ENSP00000265598	ENSP00000499683	Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity.	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	0.410
NAPSA	CTSH	ENSP00000253719	ENSP00000220166	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	0.672
NAPSA	SFTPB	ENSP00000253719	ENSP00000499683	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	0.797
NAPSA	SFTPC	ENSP00000253719	ENSP00000316152	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	0.736
SFTPB	ABCA3	ENSP00000499683	ENSP00000301732	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	0.960
SFTPB	CTSH	ENSP00000499683	ENSP00000220166	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	0.715
SFTPB	LAMP3	ENSP00000499683	ENSP00000265598	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity.	0.410
SFTPB	NAPSA	ENSP00000499683	ENSP00000253719	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.797
SFTPB	SFTPC	ENSP00000499683	ENSP00000316152	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	0.999
SFTPC	ABCA3	ENSP00000316152	ENSP00000301732	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family.	0.899
SFTPC	CTSH	ENSP00000316152	ENSP00000220166	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.	0.581
SFTPC	NAPSA	ENSP00000316152	ENSP00000253719	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.736
SFTPC	SFTPB	ENSP00000316152	ENSP00000499683	Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	0.999