node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | ARSB | ENSP00000216124 | ENSP00000264914 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | 0.950 |
ARSA | ARSD | ENSP00000216124 | ENSP00000370546 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase D. | 0.513 |
ARSA | ARSF | ENSP00000216124 | ENSP00000370519 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase F. | 0.499 |
ARSA | ARSG | ENSP00000216124 | ENSP00000407193 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | 0.924 |
ARSA | ARSH | ENSP00000216124 | ENSP00000370522 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member H. | 0.500 |
ARSA | ARSI | ENSP00000216124 | ENSP00000333395 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | 0.607 |
ARSA | ARSJ | ENSP00000216124 | ENSP00000320219 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member J. | 0.595 |
ARSA | ARSK | ENSP00000216124 | ENSP00000369346 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member K. | 0.621 |
ARSA | ARSL | ENSP00000216124 | ENSP00000500220 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase L; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. | 0.498 |
ARSA | STS | ENSP00000216124 | ENSP00000217961 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.517 |
ARSA | SUMF1 | ENSP00000216124 | ENSP00000272902 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.957 |
ARSA | SUMF2 | ENSP00000216124 | ENSP00000498402 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.777 |
ARSB | ARSA | ENSP00000264914 | ENSP00000216124 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.950 |
ARSB | ARSD | ENSP00000264914 | ENSP00000370546 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase D. | 0.602 |
ARSB | ARSF | ENSP00000264914 | ENSP00000370519 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase F. | 0.617 |
ARSB | ARSG | ENSP00000264914 | ENSP00000407193 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | 0.940 |
ARSB | ARSH | ENSP00000264914 | ENSP00000370522 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase family member H. | 0.625 |
ARSB | ARSI | ENSP00000264914 | ENSP00000333395 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | 0.432 |
ARSB | ARSJ | ENSP00000264914 | ENSP00000320219 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase family member J. | 0.426 |
ARSB | ARSK | ENSP00000264914 | ENSP00000369346 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase family member K. | 0.827 |