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RPL18A RPL18A RPL19 RPL19 RPS12 RPS12 RPS4Y1 RPS4Y1 RPL35 RPL35 RPL8 RPL8 RPL3L RPL3L RPS11 RPS11 RPS27A RPS27A RPL37 RPL37 RPS3 RPS3 RPL29 RPL29 APEH APEH RPS23 RPS23 RPL10L RPL10L N6AMT1 N6AMT1 RPL13 RPL13 RPL15 RPL15 RPL38 RPL38 RPL4 RPL4 RPS15A RPS15A RPS27L RPS27L RPL7 RPL7 GSPT2 GSPT2 RPS2 RPS2 RPS21 RPS21 RPL3 RPL3 RPL36AL RPL36AL RPL27A RPL27A RPL21 RPL21 RPLP1 RPLP1 RPS3A RPS3A RPL22L1 RPL22L1 RPL22 RPL22 RPS26 RPS26 ETF1 ETF1 RPL12 RPL12 RPL39 RPL39 RPL5 RPL5 RPL7A RPL7A RPS4X RPS4X RPL10A RPL10A RPS16 RPS16 RPS6 RPS6 RPS9 RPS9 RPL13A RPL13A RPL24 RPL24 RPL34 RPL34 RPS29 RPS29 RPL14 RPL14 RPS8 RPS8 RPS14 RPS14 RPL31 RPL31 UBA52 UBA52 RPL23A RPL23A RPSA RPSA RPL39L RPL39L RPS18 RPS18 GSPT1 GSPT1 RPL6 RPL6 RPL36A RPL36A RPL10 RPL10 RPS24 RPS24 RPL32 RPL32 RPL37A RPL37A RPL23 RPL23 RPL30 RPL30 RPL26L1 RPL26L1 RPS20 RPS20 RPLP2 RPLP2 RPS25 RPS25 RPS13 RPS13 TRMT112 TRMT112 RPL18 RPL18 RPLP0 RPLP0 RPL28 RPL28 RPL26 RPL26 RPL17 RPL17 RPL36 RPL36 RPL27 RPL27 RPS15 RPS15 RPS19 RPS19 RPS28 RPS28 RPS5 RPS5 RPS10 RPS10 RPS4Y2 RPS4Y2 RPL9 RPL9 RPS7 RPS7 RPL35A RPL35A RPL11 RPL11 RPS17 RPS17 RPS27 RPS27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL18ARibosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. (176 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
RPS12Ribosomal protein S12. (132 aa)
RPS4Y1Ribosomal protein S4 Y-linked 1; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPL3560S ribosomal protein L35; Component of the large ribosomal subunit. (123 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit. (257 aa)
RPL3LRibosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family. (407 aa)
RPS11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
RPL3760S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa)
RPL2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (159 aa)
APEHAcylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. (732 aa)
RPS2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
RPL10L60S ribosomal protein L10-like; May play a role in compensating for the inactivated X-linked gene during spermatogenesis. (214 aa)
N6AMT1Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly- Gln-Xaa-Xaa-Xaa-Arg motif (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)- methyladenosine). N(6)-methyladenosine (m6A) DNA is significantly [...] (214 aa)
RPL13Ribosomal protein L13. (211 aa)
RPL15Ribosomal protein L15. (204 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
RPL4Ribosomal protein L4. (427 aa)
RPS15A40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis. (130 aa)
RPS27LRibosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
RPL760S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs. (248 aa)
GSPT2Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. (628 aa)
RPS2Ribosomal protein S2. (293 aa)
RPS21Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
RPL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
RPL36ALRibosomal protein L36a like; Belongs to the eukaryotic ribosomal protein eL42 family. (106 aa)
RPL27ARibosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. (148 aa)
RPL2160S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. (160 aa)
RPLP160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. (264 aa)
RPL22L1Ribosomal protein L22 like 1; Belongs to the eukaryotic ribosomal protein eL22 family. (122 aa)
RPL22Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family. (128 aa)
RPS26Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
ETF1Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. (437 aa)
RPL1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
RPL39Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RPL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
RPL7ARibosomal protein L7a. (266 aa)
RPS4XRibosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. (217 aa)
RPS16Ribosomal protein S16. (152 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPS9Ribosomal protein S9. (194 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppre [...] (203 aa)
RPL24Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
RPL3460S ribosomal protein L34; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL34 family. (117 aa)
RPS29Ribosomal protein S29. (67 aa)
RPL1460S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family. (215 aa)
RPS8Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
RPS14Ribosomal protein S14. (151 aa)
RPL31Ribosomal protein L31. (128 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPL23A60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. (156 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] (300 aa)
RPL39LRibosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RPS1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
GSPT1Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular gen [...] (637 aa)
RPL660S ribosomal protein L6; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL6 family. (288 aa)
RPL36ARibosomal protein L36a. (142 aa)
RPL1060S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. (214 aa)
RPS2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. (289 aa)
RPL32Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
RPL37ARibosomal protein L37a. (92 aa)
RPL23Ribosomal protein L23. (140 aa)
RPL30Ribosomal protein L30. (115 aa)
RPL26L1Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family. (145 aa)
RPS20Ribosomal protein S20. (142 aa)
RPLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis. (115 aa)
RPS25Ribosomal protein S25. (125 aa)
RPS13Ribosomal protein S13. (151 aa)
TRMT112Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to [...] (125 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
RPL2860S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (170 aa)
RPL2660S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
RPL1760S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family. (184 aa)
RPL3660S ribosomal protein L36; Component of the large ribosomal subunit. (105 aa)
RPL2760S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs. (136 aa)
RPS15Ribosomal protein S15. (152 aa)
RPS1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
RPS28Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
RPS540S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
RPS1040S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family. (165 aa)
RPS4Y2Ribosomal protein S4 Y-linked 2; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
RPL9Ribosomal protein L9. (192 aa)
RPS740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
RPL35A60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa)
RPS17Ribosomal protein S17. (135 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs ; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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