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ITGB5 ITGB5 COL6A3 COL6A3 CPNE2 CPNE2 CACHD1 CACHD1 ITGA1 ITGA1 GTF2H2 GTF2H2 ITIH1 ITIH1 CPNE7 CPNE7 CPNE5 CPNE5 COL21A1 COL21A1 CLCA1 CLCA1 ITIH6 ITIH6 COCH COCH ITIH3 ITIH3 B4E1Z4_HUMAN B4E1Z4_HUMAN CLCA4 CLCA4 MDN1 MDN1 ITGA10 ITGA10 PSMD4 PSMD4 SVEP1 SVEP1 VWA5A VWA5A VWA5B2 VWA5B2 MATN3 MATN3 COL28A1 COL28A1 COL6A1 COL6A1 COL20A1 COL20A1 COL6A6 COL6A6 ITIH2 ITIH2 MATN1 MATN1 MATN4 MATN4 ITIH5 ITIH5 CACNA2D1 CACNA2D1 VWA2 VWA2 XRCC5 XRCC5 VWA3A VWA3A ITGAD ITGAD CLCA2 CLCA2 CPNE9 CPNE9 CACNA2D4 CACNA2D4 CFB CFB VWA1 VWA1 VWA3B VWA3B CACNA2D2 CACNA2D2 CACNA2D3 CACNA2D3 GTF2H2C GTF2H2C CPNE6 CPNE6 ITGAX ITGAX CPNE3 CPNE3 CPNE4 CPNE4 ANTXRL ANTXRL INTS6L INTS6L ITGAM ITGAM INTS14 INTS14 PARP4 PARP4 VWA8 VWA8 VIT VIT VWA5B1 VWA5B1 COL6A5 COL6A5 ITGAE ITGAE VWF VWF ITIH4 ITIH4 MATN2 MATN2 ITGAL ITGAL COL7A1 COL7A1 CPNE8 CPNE8 ITGA11 ITGA11 COL12A1 COL12A1 CPNE1 CPNE1 INTS6 INTS6 ANTXR2 ANTXR2 COL22A1 COL22A1 ANTXR1 ANTXR1 COL6A2 COL6A2 C2 C2 COL14A1 COL14A1 ITGA2 ITGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB5Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (799 aa)
COL6A3Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. (3177 aa)
CPNE2Copine-2; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium- dependent cell membrane binding properties. Belongs to the copine family. (548 aa)
CACHD1VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels. (1223 aa)
ITGA1Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. (1179 aa)
GTF2H2General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (395 aa)
ITIH1Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (911 aa)
CPNE7Copine-7; Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family. (633 aa)
CPNE5Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes ; Belongs to the copine family. (593 aa)
COL21A1Collagen type XXI alpha 1 chain. (957 aa)
CLCA1Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. (914 aa)
ITIH6Inter-alpha-trypsin inhibitor heavy chain family member 6. (1313 aa)
COCHCochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. (615 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (890 aa)
B4E1Z4_HUMANcDNA FLJ55673, highly similar to Complement factor B; Belongs to the peptidase S1 family. (1266 aa)
CLCA4Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance. (919 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] (5596 aa)
ITGA10Integrin alpha-10; Integrin alpha-10/beta-1 is a receptor for collagen; Belongs to the integrin alpha chain family. (1167 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] (380 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process. (3571 aa)
VWA5AVon Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. (786 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)
MATN3Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. (486 aa)
COL28A1Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family. (1125 aa)
COL6A1Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein. (1028 aa)
COL20A1Collagen alpha-1(XX) chain; Probable collagen protein. (1284 aa)
COL6A6Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein. (2263 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family. (946 aa)
MATN1Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. (496 aa)
MATN4Matrilin-4; Major component of the extracellular matrix of cartilage. (581 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor. (942 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation- contraction coupling (By similarity). (1091 aa)
VWA2Von Willebrand factor A domain containing 2. (755 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (732 aa)
VWA3AVon Willebrand factor A domain containing 3A. (1184 aa)
ITGADIntegrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. (1161 aa)
CLCA2Calcium-activated chloride channel regulator 2, 109 kDa form; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family. (943 aa)
CPNE9Copine-9; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes. (553 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. (1137 aa)
CFBComplement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. (764 aa)
VWA1Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. (445 aa)
VWA3BVon Willebrand factor A domain containing 3B. (1294 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. (1150 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). (1091 aa)
GTF2H2CGeneral transcription factor IIH subunit 2-like protein; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. (395 aa)
CPNE6Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes. (612 aa)
ITGAXIntegrin alpha-X; Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. (1169 aa)
CPNE3Copine-3; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. Belongs to the copine family. (537 aa)
CPNE4Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family. (575 aa)
ANTXRLAnthrax toxin receptor-like; ANTXR like. (631 aa)
INTS6LIntegrator complex subunit 6 like. (898 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN [...] (1153 aa)
INTS14Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family. (461 aa)
PARP4Protein mono-ADP-ribosyltransferase PARP4; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. (1724 aa)
VWA8Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro. (1905 aa)
VITVitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. (693 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1220 aa)
COL6A5Collagen alpha-5(VI) chain; Collagen VI acts as a cell-binding protein. (2611 aa)
ITGAEIntegrin alpha-E heavy chain; Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. (1179 aa)
VWFVon Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. (2813 aa)
ITIH435 kDa inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. (930 aa)
MATN2Matrilin-2; Involved in matrix assembly. (956 aa)
ITGALIntegrin alpha-L; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutroph [...] (1170 aa)
COL7A1Collagen alpha-1(VII) chain; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. (2944 aa)
CPNE8Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family. (564 aa)
ITGA11Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. (1188 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3063 aa)
CPNE1Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium- dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium- independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcription [...] (542 aa)
INTS6Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. (887 aa)
ANTXR2Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family. (489 aa)
COL22A1Collagen alpha-1(XXII) chain; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (1626 aa)
ANTXR1Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (564 aa)
COL6A2Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. (1019 aa)
C2Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family. (752 aa)
COL14A1Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). (1796 aa)
ITGA2Integrin alpha-2; Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. (1181 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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