STRINGSTRING
POTEI POTEI ACTL6B ACTL6B ACTR6 ACTR6 ACTA2 ACTA2 ACTR5 ACTR5 ACTR3C ACTR3C ACTL6A ACTL6A ACTG2 ACTG2 POTEJ POTEJ ACTB ACTB ACTG1 ACTG1 POTEE POTEE ACTR10 ACTR10 ACTR3B ACTR3B ACTR3 ACTR3 ACTR1B ACTR1B ACTC1 ACTC1 ACTL9 ACTL9 ACTL10 ACTL10 ACTRT3 ACTRT3 ACTL7A ACTL7A ACTR8 ACTR8 ACTBL2 ACTBL2 ACTA1 ACTA1 ACTR1A ACTR1A ACTRT1 ACTRT1 ACTL7B ACTL7B ACTL8 ACTL8 ACTR2 ACTR2 ACTRT2 ACTRT2 POTEF POTEF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POTEIPOTE ankyrin domain family member I; In the N-terminal section; belongs to the POTE family. (1075 aa)
ACTL6BActin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] (426 aa)
ACTR6Actin related protein 6; Belongs to the actin family. ARP6 subfamily. (396 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
ACTR5Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. (607 aa)
ACTR3CActin-related protein 3C; May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. (210 aa)
ACTL6AActin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa)
ACTG2Actin, gamma-enteric smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa)
POTEJPOTE ankyrin domain family member J; In the N-terminal section; belongs to the POTE family. (1038 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ACTG1Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (375 aa)
POTEEPOTE ankyrin domain family member E; In the C-terminal section; belongs to the actin family. (1075 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (417 aa)
ACTR3BActin-related protein 3B; Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. (418 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (418 aa)
ACTR1BBeta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. (376 aa)
ACTC1Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
ACTL9Actin-like protein 9; Actin like 9. (416 aa)
ACTL10Actin-like protein 10; Actin like 10; Belongs to the actin family. (245 aa)
ACTRT3Actin related protein T3. (372 aa)
ACTL7AActin-like protein 7A; Actin like 7A; Belongs to the actin family. (435 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
ACTBL2Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
ACTA1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
ACTR1AAlpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. (376 aa)
ACTRT1Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. (376 aa)
ACTL7BActin-like protein 7B; Actin like 7B; Belongs to the actin family. (415 aa)
ACTL8Actin-like protein 8; Actin like 8. (366 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (399 aa)
ACTRT2Actin related protein T2. (377 aa)
POTEFPOTE ankyrin domain family member F; In the C-terminal section; belongs to the actin family. (1075 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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