STRINGSTRING
OIP5 OIP5 CRBN CRBN MIS18A MIS18A YPEL2 YPEL2 YPEL1 YPEL1 YPEL5 YPEL5 YPEL3 YPEL3 YPEL4 YPEL4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OIP5Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family. (229 aa)
CRBNProtein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding [...] (442 aa)
MIS18AProtein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. (233 aa)
YPEL2Protein yippee-like 2; Yippee like 2. (119 aa)
YPEL1Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Belongs to the yippee family. (119 aa)
YPEL5Protein yippee-like 5; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for normal cell proliferation (By similarity). (121 aa)
YPEL3Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. (157 aa)
YPEL4Protein yippee-like 4; Yippee like 4; Belongs to the yippee family. (127 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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